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Its sensing ability towards Ni<jats:sup>2+<\/jats:sup> ion was examined showing a binding constant of 1.04\u2009\u00d7\u200910<jats:sup>5<\/jats:sup> compared with other suitable metal cations (Ca<jats:sup>2+<\/jats:sup>, Co<jats:sup>2+<\/jats:sup>, Cr<jats:sup>3+<\/jats:sup>, Ag<jats:sup>+<\/jats:sup>, Pb<jats:sup>2+<\/jats:sup>, Fe<jats:sup>3+<\/jats:sup>, Mg<jats:sup>2+<\/jats:sup>, and K<jats:sup>+<\/jats:sup>) using ultraviolet\u2013visible (UV\u2013vis) and fluorescence spectroscopic studies. The minimum concentration of Ni<jats:sup>2+<\/jats:sup> ions and limit of detection was found to be 9.4\u2009\u03bcM. A job's plot gave the binding stoichiometry ratio of oxadiazole derivative 2 vs Ni<jats:sup>2+<\/jats:sup> ions as 2:1. Furthermore, the intercalative binding mode of oxadiazole derivative 2 with calf thymus DNA was supported by ultraviolet\u2013visible (UV\u2013vis) and fluorescent light, viscosity, cyclic voltammetry, time\u2010resolved fluorescence, and circular dichroism measurements. The molecular docking result gave the binding score for oxadiazole derivative 2 as \u22126.5\u2009kcal\/mol, which further confirmed the intercalative interaction. In addition, the antifungal activity of oxadiazole derivative 2 was also screened against several fungal strains (<jats:styled-content style=\"fixed-case\"><jats:italic>C. albicans<\/jats:italic><\/jats:styled-content>, <jats:styled-content style=\"fixed-case\"><jats:italic>C. glabrata<\/jats:italic><\/jats:styled-content>, and <jats:styled-content style=\"fixed-case\"><jats:italic>C. tropicalis<\/jats:italic><\/jats:styled-content>) by broth dilution and disc diffusion methods. In antioxidant studies, the oxadiazole derivative 2 showed potential scavenging activity against 2,2\u2010diphenyl\u20101\u2010picrylhydrazyl and H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub> free radicals.<\/jats:p>","DOI":"10.1002\/bio.4184","type":"journal-article","created":{"date-parts":[[2022,1,5]],"date-time":"2022-01-05T19:53:15Z","timestamp":1641412395000},"page":"408-421","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["2\u2010Amino\u20105\u2010substituted\u20101,3,4\u2010oxadiazole as chemosensor for Ni(II) ion detection: antifungal, antioxidant, DNA binding, and molecular docking studies"],"prefix":"10.1002","volume":"37","author":[{"given":"Razia","family":"Sultana","sequence":"first","affiliation":[{"name":"Department of Chemistry Jamia Millia Islamia  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rizwan","family":"Arif","sequence":"additional","affiliation":[{"name":"Department of Chemistry Lingayas Vidyapeeth  Faridabad Haryana India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manish","family":"Rana","sequence":"additional","affiliation":[{"name":"Department of Chemistry Jamia Millia Islamia  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saiema","family":"Ahmedi","sequence":"additional","affiliation":[{"name":"Department of Biosciences Jamia Millia Islamia  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rabiya","family":"Mehandi","sequence":"additional","affiliation":[{"name":"Department of Chemistry Jamia Millia Islamia  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Akrema","sequence":"additional","affiliation":[{"name":"Department of Chemistry Jamia Millia Islamia  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikhat","family":"Manzoor","sequence":"additional","affiliation":[{"name":"Department of Biosciences Jamia Millia Islamia  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7139-6976","authenticated-orcid":false,"family":"Rahisuddin","sequence":"additional","affiliation":[{"name":"Department of Chemistry Jamia Millia Islamia  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,1,30]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_6_2_1","DOI":"10.1016\/j.saa.2019.117993"},{"doi-asserted-by":"publisher","key":"e_1_2_6_3_1","DOI":"10.1002\/bio.3695"},{"doi-asserted-by":"publisher","key":"e_1_2_6_4_1","DOI":"10.1002\/bio.3443"},{"doi-asserted-by":"publisher","key":"e_1_2_6_5_1","DOI":"10.1002\/anie.201001373"},{"doi-asserted-by":"publisher","key":"e_1_2_6_6_1","DOI":"10.1016\/S0010-8545(00)00242-3"},{"doi-asserted-by":"publisher","key":"e_1_2_6_7_1","DOI":"10.1016\/S0168-6445(03)00042-1"},{"doi-asserted-by":"publisher","key":"e_1_2_6_8_1","DOI":"10.1074\/jbc.R900020200"},{"key":"e_1_2_6_9_1","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1016\/S1452-3981(23)15205-9","volume":"4","author":"Fu G. 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