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The approach depended on measuring the first derivative synchronous peak amplitude (<jats:sup>1<\/jats:sup>D) of both drugs at \u2206\u03bb\u2009=\u200960\u2009nm in a Tween\u201080 micellar system. The method was rectilinear alongside the concentration ranges 0.02\u20130.4 \u03bcg\/ml and 0.05\u20131.0 \u03bcg\/ml at 269.5\u2009nm and 378.5\u2009nm for IVB and FLD, respectively. The proposed method was validated by following the International Council for Harmonization guidelines. The method was successfully applied without interference for laboratory\u2010prepared synthetic mixtures, single pharmaceutical preparations, and within spiked biological fluids with acceptable percentage recoveries. A comparison of the performance of the suggested method with other methods, showed no discrepancy. The method\u2019s ecofriendly property evaluated using three different tools, confirming an excellent green method.<\/jats:p>","DOI":"10.1002\/bio.4187","type":"journal-article","created":{"date-parts":[[2022,1,7]],"date-time":"2022-01-07T13:13:45Z","timestamp":1641561225000},"page":"569-576","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Micellar\u2010emphasized simultaneous determination of ivabradine hydrochloride and felodipine using synchronous spectrofluorimetry"],"prefix":"10.1002","volume":"37","author":[{"given":"Eman","family":"Yosrey","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy Mansoura University  Mansoura Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3953-7169","authenticated-orcid":false,"given":"Heba","family":"Elmansi","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy Mansoura University  Mansoura Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeinab A.","family":"Sheribah","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy Mansoura University  Mansoura Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed El\u2010Sayed","family":"Metwally","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy Mansoura University  Mansoura Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,2,9]]},"reference":[{"key":"e_1_2_6_2_1","volume-title":"Martindale: the complete drug reference","author":"Parfitt K.","year":"1999"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.08.038"},{"issue":"12","key":"e_1_2_6_4_1","first-page":"810","volume":"40","author":"Tse S.","year":"2015","journal-title":"Pharma. 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