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Here, we synthesized biogenic cadmium sulphide (CdS) QDs using green tea extract as the reducing agent to produce particles that were homogeneous and a smaller size of 2\u20134\u2009nm. We also elucidated the (a) protein binding, (b) antibacterial use and (c) sensing applications of biogenic CdS QDs in this present work. The biosynthesized CdS QDs were found to have extensive antibacterial activity against both Gram\u2010negative <jats:styled-content style=\"fixed-case\"><jats:italic>Escherichia coli<\/jats:italic><\/jats:styled-content> and Gram\u2010positive <jats:styled-content style=\"fixed-case\"><jats:italic>Enterococcus faecalis<\/jats:italic><\/jats:styled-content> bacterial strains. The introduction of QDs in biological medium can lead to the formation of protein\u2013QD complexes; therefore we investigated the binding interaction of CdS QDs with the carrier protein human serum albumin (HSA) <jats:italic>in vitro<\/jats:italic>. The synthesized CdS QDs quenched the intrinsic fluorescence of HSA through a static quenching mechanism and the binding constant (<jats:italic>K<\/jats:italic><jats:sub><jats:italic>b<\/jats:italic><\/jats:sub>) was in the order of 10<jats:sup>4<\/jats:sup>\u2009M<jats:sup>\u22121<\/jats:sup>. It was also observed that the presence of biogenic CdS QDs affected the HSA\u2013ligand interactions <jats:italic>in vitro<\/jats:italic>. The synthesized CdS made highly effective sensors for tetracycline, rifampicin, and bilirubin with limit of detection (LOD) values of 99, 141 and 29\u2009ng\/ml, respectively.<\/jats:p>","DOI":"10.1002\/bio.4228","type":"journal-article","created":{"date-parts":[[2022,3,17]],"date-time":"2022-03-17T02:45:11Z","timestamp":1647485111000},"page":"837-853","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Interaction properties of biosynthesized cadmium sulphide quantum dots with human serum albumin: further investigation of antibacterial activities and sensing applications"],"prefix":"10.1002","volume":"37","author":[{"given":"Mahabul","family":"Haque","sequence":"first","affiliation":[{"name":"Department of Chemistry National Institute of Technology Meghalaya  Shillong India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sona","family":"Lyndem","sequence":"additional","affiliation":[{"name":"Department of Chemistry National Institute of Technology Meghalaya  Shillong India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1902-403X","authenticated-orcid":false,"given":"Atanu","family":"Singha Roy","sequence":"additional","affiliation":[{"name":"Department of Chemistry National Institute of Technology Meghalaya  Shillong India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,3,28]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/nl071546n"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2014.08.003"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2008.09.005"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1039\/b902711b"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2011.10.080"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2011.10.070"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2011.03.006"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nano.2011.04.011"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tiv.2009.06.020"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0024406"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2012.04.045"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.materresbull.2016.08.049"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/cm3035642"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/jp0563585"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1070\/RCR4656"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.6b16170"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1387-7003(01)00172-1"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1021\/ie201826e"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matpr.2019.06.003"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpha.2020.12.003"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/1556-276X-9-686"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1039\/c1nr10399g"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matlet.2009.02.028"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsanm.8b00147"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1117\/1.2764463"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2011.08.048"},{"key":"e_1_2_7_28_1","first-page":"1321","volume":"17","author":"Jiao Y.","year":"2018","journal-title":"Exp. 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