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Tramadol and celecoxib were recently released as a new drug combination to alleviate intense, sudden pain when other pain medications had failed. The technique entailed taking measurements of the fluorescence amplitudes of the synchronized spectra at \u0394\u03bb\u2009=\u2009100\u2009nm. Excitation was made at 220\u2009nm and 264\u2009nm, whereas the emission points were 282\u2009nm and 368\u2009nm for tramadol and celecoxib, respectively. This technique offers linearity of\u200940\u2013400\u2009ng\/ml and 100\u20132000\u2009ng\/ml for tramadol and celecoxib, respectively. Complex formation between the cited medications with the surfactant sodium dodecyl sulphate enhanced the fluorescence intensity and other control parameters. Tramadol and celecoxib were both determined in spiked human plasma using the current technique with marked percentage recoveries of 98.63\u2009\u00b1\u00a06.30% and 99.32\u2009\u00b1\u00a06.67%, respectively. Last, the research was extended to check the greenness profile of the finally optimized method and the results revealed excellent eco\u2010friendliness. Three greenness assessment tools were used including Eco\u2010scale, the Green Analytical Procedure Index tool, and the AGREE calculator. Sustainable development, economic feasibility, and environmental soundness were all considered throughout the development of the present technique. The approach was validated in accordance with the requirements provided by the International Council for Harmonization.<\/jats:p>","DOI":"10.1002\/bio.4458","type":"journal-article","created":{"date-parts":[[2023,2,8]],"date-time":"2023-02-08T22:25:54Z","timestamp":1675895154000},"page":"389-400","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Green micelle and complex inclusion enhance synchronous spectrofluorimetric quantification of a novel analgesic combination: Tramadol and celecoxib in tablet dosage form and spiked human plasma"],"prefix":"10.1002","volume":"38","author":[{"given":"Eman A.","family":"Bahgat","sequence":"first","affiliation":[{"name":"Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy Zagazig University  Zagazig Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisham","family":"Hashem","sequence":"additional","affiliation":[{"name":"Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy Zagazig University  Zagazig Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanaa","family":"Saleh","sequence":"additional","affiliation":[{"name":"Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy Zagazig University  Zagazig Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0681-7989","authenticated-orcid":false,"given":"Ebraam B.","family":"Kamel","sequence":"additional","affiliation":[{"name":"Pharmaceutical Chemistry Department, Faculty of Pharmacy Egyptian Russian University  Badr City Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maya S.","family":"Eissa","sequence":"additional","affiliation":[{"name":"Pharmaceutical Chemistry Department, Faculty of Pharmacy Egyptian Russian University  Badr City Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,2,20]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.saa.2018.06.057"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/bio.3475"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/bio.3969"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2313(78)90083-2"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0026-265X(85)90007-4"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1039\/b9ay00208a"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.saa.2020.118533"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.12.085"},{"key":"e_1_2_6_10_1","first-page":"57","volume":"10","author":"Vinay K. 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