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In this study, two spectroscopical techniques, spectrofluorimetric and resonance Rayleigh scattering (RRS), were utilized to quantify naftidrofuryl in its pharmaceutical samples. The developed methodologies in this study rely on a facile process of forming an association complex between erythrosine B reagent and naftidrofuryl under acidic conditions. The fluorimetric assay is based on the ability of naftidrofuryl to quench and decrease the native fluorescence intensity of the reagent when measured at \n = 550\u2009nm (\n = 526\u2009nm). Under similar reaction conditions, the RRS method relies on the observed amplification in the RRS spectrum of the reagent at a wavelength of 577\u2009nm following its interaction with naftidrofuryl. The methods exhibited linearity within the ranges 0.2\u20131.6\u00a0\u03bcg\/ml (r<jats:sup>2<\/jats:sup>\u00a0=\u00a00.999) and 0.1\u20131.4\u00a0\u03bcg\/ml (r<jats:sup>2<\/jats:sup>\u00a0=\u00a00.9994), with limit of quantitation values of 0.146 and 0.099\u2009\u03bcg\/ml, and limit of detection values of 0.048 and 0.032\u2009\u03bcg\/ml, for the fluorometric and the RRS methods, respectively. Moreover, the quenching between the dye and naftidrofuryl was studied using Stern\u2013Volmer analysis, and the methodologies were experimentally optimized and validated. Additionally, acceptable recoveries were achieved when the procedures were applied to determine naftidrofuryl in pharmaceutical samples.<\/jats:p>","DOI":"10.1002\/bio.4570","type":"journal-article","created":{"date-parts":[[2023,8,9]],"date-time":"2023-08-09T10:26:01Z","timestamp":1691576761000},"page":"1836-1843","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Validated spectrofluorimetric and resonance Rayleigh scattering methods for determining naftidrofuryl in varied pharmaceutical samples based on its interaction with erythrosin B"],"prefix":"10.1002","volume":"38","author":[{"given":"Mona Saad","family":"Binkadem","sequence":"first","affiliation":[{"name":"Department of Chemistry College of Science, University of Jeddah  P.O. Box 80327 Jeddah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huda Salem","family":"AlSalem","sequence":"additional","affiliation":[{"name":"Department of Chemistry College of Science, Princess Nourah bint Abdulrahman University  P.O. Box 84428 Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soha Talal","family":"Al\u2010Goul","sequence":"additional","affiliation":[{"name":"Department of Chemistry, College of Sciences &amp; Arts King Abdulaziz University  Rabigh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9774-0587","authenticated-orcid":false,"given":"Mohamed A.","family":"El Hamd","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences College of Pharmacy, Shaqra University  Shaqra 11961 Saudi Arabia"},{"name":"Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy South Valley University  Qena 83523 Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5965-7387","authenticated-orcid":false,"given":"Mohamed","family":"Oraby","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy Sohag University  Sohag 82524 Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faten M.","family":"Ali Zainy","sequence":"additional","affiliation":[{"name":"Chemistry Department, Faculty of Science University of Jeddah  P.O. 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