{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T20:36:02Z","timestamp":1773520562180,"version":"3.50.1"},"reference-count":51,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,5,8]],"date-time":"2024-05-08T00:00:00Z","timestamp":1715126400000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Luminescence"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A spectrofluorimetric method using fluorescent carbon dots (CDs) was developed for the selective detection of azelnidipine (AZEL) pharmaceutical in the presence of other drugs. In this study, N\u2010doped CDs (N\u2010CDs) were synthesized through a single\u2010step hydrothermal process, using citric acid and urea as precursor materials. The prepared N\u2010CDs showed a highly intense blue fluorescence emission at 447\u2009nm, with a photoluminescence quantum yield of ~21.15% and a fluorescence lifetime of 0.47\u2009ns. The N\u2010CDs showed selective fluorescence quenching in the presence of all three antihypertensive drugs, which was used as a successful detection platform for the analysis of AZEL. The photophysical properties, UV\u2013vis light absorbance, fluorescence emission, and lifetime measurements support the interaction between N\u2010CDs and AZEL, leading to fluorescence quenching of N\u2010CDs as a result of ground\u2010state complex formation followed by a static fluorescence quenching phenomenon. The detection platform showed linearity in the range 10\u2013200\u2009\u03bcg\/ml (<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u20090.9837). The developed method was effectively utilized for the quantitative analysis of AZEL in commercially available pharmaceutical tablets, yielding results that closely align with those obtained from the standard method (UV spectroscopy). With a score of 0.76 on the \u2018Analytical GREEnness (AGREE)\u2019 scale, the developed analytical method, incorporating 12 distinct green analytical chemistry components, stands out as an important technique for estimating AZEL.<\/jats:p>","DOI":"10.1002\/bio.4738","type":"journal-article","created":{"date-parts":[[2024,5,8]],"date-time":"2024-05-08T21:50:25Z","timestamp":1715205025000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Selective detection of azelnidipine in pharmaceuticals via carbon dot mediated spectrofluorimetric method: A green approach"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7783-6485","authenticated-orcid":false,"given":"Sandesh R.","family":"Lodha","sequence":"first","affiliation":[{"name":"Maliba Pharmacy College Uka Tarsadia University  Bardoli Gujarat India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anil H.","family":"Gore","sequence":"additional","affiliation":[{"name":"Tarsadia Institute of Chemical Science Uka Tarsadia University  Bardoli Gujarat India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jesika G.","family":"Merchant","sequence":"additional","affiliation":[{"name":"Maliba Pharmacy College Uka Tarsadia University  Bardoli Gujarat India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arya J.","family":"Pillai","sequence":"additional","affiliation":[{"name":"Maliba Pharmacy College Uka Tarsadia University  Bardoli Gujarat India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hetal P.","family":"Patel","sequence":"additional","affiliation":[{"name":"Maliba Pharmacy College Uka Tarsadia University  Bardoli Gujarat India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Furqan A.","family":"Maulvi","sequence":"additional","affiliation":[{"name":"Maliba Pharmacy College Uka Tarsadia University  Bardoli Gujarat India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pravin O.","family":"Patil","sequence":"additional","affiliation":[{"name":"H.R Patel Institute of Pharmaceutical Education and Research  Shirpur Maharashtra India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gajanan G.","family":"Kalyankar","sequence":"additional","affiliation":[{"name":"Maliba Pharmacy College Uka Tarsadia University  Bardoli Gujarat India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shrikant V.","family":"Joshi","sequence":"additional","affiliation":[{"name":"Maliba Pharmacy College Uka Tarsadia University  Bardoli Gujarat India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paresh N.","family":"Patel","sequence":"additional","affiliation":[{"name":"Tarsadia Institute of Chemical Science Uka Tarsadia University  Bardoli Gujarat India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shailesh A.","family":"Shah","sequence":"additional","affiliation":[{"name":"Maliba Pharmacy College Uka Tarsadia University  Bardoli Gujarat India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dinesh R.","family":"Shah","sequence":"additional","affiliation":[{"name":"Maliba Pharmacy College Uka Tarsadia University  Bardoli Gujarat India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,5,8]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.5005\/jp\/books\/10282"},{"key":"e_1_2_10_3_1","unstructured":"NCBI.PubChem Compound Summary for CID 65948 Azelnidipine.https:\/\/pubchem.ncbi.nlm.nih.gov\/compound\/Azelnidipine(accessed: February 9 2023)."},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/4965138"},{"issue":"8","key":"e_1_2_10_5_1","first-page":"198","volume":"6","author":"Rele R.","year":"2014","journal-title":"J. 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