{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T00:51:08Z","timestamp":1759971068681,"version":"build-2065373602"},"reference-count":34,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,5,28]],"date-time":"2024-05-28T00:00:00Z","timestamp":1716854400000},"content-version":"vor","delay-in-days":27,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006143","name":"Department of Science and Technology, Government of Kerala","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006143","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Luminescence"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The fear of an increase in blood sugar can be very traumatic. Being diabetic either type I or type II leads to a disorder called diabetes distress having traits of stress, depression, and anxiety. Among risk factors of diabetes mellitus heavy and trace metal toxicity emerges as new risk factors reported in many studies. In this study we target toxic metals, viz., Ni<jats:sup>2+<\/jats:sup>, Zn<jats:sup>2+<\/jats:sup>, and Cu<jats:sup>2+<\/jats:sup>, involved in the pathogenesis of diabetes and diabetic stress with naphthazarin esters. The compounds C1\u2013C3 isolated from the leaves and roots of <jats:italic>Arnebia <jats:styled-content style=\"fixed-case\">guttata<\/jats:styled-content><\/jats:italic> were tested for their metal\u2010binding ability in an aqueous medium in UV\u2013Visible and nuclear magnetic resonance (NMR) studies. These probes are well\u2010known naphthoquinones present in <jats:italic>the Arnebia<\/jats:italic> species. In the UV\u2013Visible titrations of compounds C1\u2013C3 with Na<jats:sup>2+<\/jats:sup>, K<jats:sup>2+<\/jats:sup>, Zn<jats:sup>2+<\/jats:sup>, Ca<jats:sup>2+<\/jats:sup>, Cu<jats:sup>2+<\/jats:sup>, Mg<jats:sup>2+<\/jats:sup>, Co<jats:sup>2+<\/jats:sup>, and Ni<jats:sup>2+<\/jats:sup> ions, significant binding was observed with Ni<jats:sup>2+<\/jats:sup>, Cu<jats:sup>2+<\/jats:sup>, and Zn<jats:sup>2+<\/jats:sup> ions in MeOH\/H<jats:sub>2<\/jats:sub>O. There occurs a beautiful formation of red\u2010shifted bands between the 520 to 620 nm range with a synergistic increase in absorbance. Also, the disappearance of proton peaks in the <jats:sup>1<\/jats:sup>H NMR spectrum on addition of metal ions confirmed binding. Compounds C1\u2013C3 isolated from <jats:styled-content style=\"fixed-case\"><jats:italic>A. guttata<\/jats:italic><\/jats:styled-content> came out as potent Ni<jats:sup>2+<\/jats:sup>, Zn<jats:sup>2+<\/jats:sup>, and Cu<jats:sup>2+<\/jats:sup> sensors that are reportedly involved in islet function and induction of diabetes.<\/jats:p>","DOI":"10.1002\/bio.4761","type":"journal-article","created":{"date-parts":[[2024,5,29]],"date-time":"2024-05-29T02:53:21Z","timestamp":1716951201000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Capturing of neurotoxins causing diabetes stress and nervous breakdown in the aqueous medium by naphthazarin esters"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0835-2372","authenticated-orcid":false,"given":"Nidhi","family":"Sharma","sequence":"first","affiliation":[{"name":"Academy of Scientific and Innovative Research (AcSIR) CSIR\u2010Central Road Research Institute  New Delhi India"},{"name":"Natural Product Chemistry &amp; Process Development Lab Food and Nutraceutical Division, CSIR\u2010Institute of Himalayan Bioresource Technology  Palampur India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashu","family":"Gulati","sequence":"additional","affiliation":[{"name":"Academy of Scientific and Innovative Research (AcSIR) CSIR\u2010Central Road Research Institute  New Delhi India"},{"name":"Natural Product Chemistry &amp; Process Development Lab Food and Nutraceutical Division, CSIR\u2010Institute of Himalayan Bioresource Technology  Palampur India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,5,28]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2020-039541"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.4161\/isl.1.3.9262"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2019.02.048"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2009.11.027"},{"key":"e_1_2_9_6_1","first-page":"557","volume":"128","author":"Bernard A.","year":"2008","journal-title":"Indian J Med. 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