{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T10:37:45Z","timestamp":1782902265292,"version":"3.54.5"},"reference-count":37,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,6,4]],"date-time":"2024-06-04T00:00:00Z","timestamp":1717459200000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Luminescence"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The study's objective is to establish an eco\u2010friendly, sensitive and economical quantitative methodology for the concurrent analysis of donepezil HCl (DPZ) and trazodone HCl (TRZ) in raw materials, tablets and human plasma. The first derivative synchronous fluorescence spectroscopic (FDSFS) technique was applied at constant wavelength difference (\u2206\u03bb\u2009=\u2009120) for assessment of DPZ and TRZ at each other's zero\u2010crossing point at 279\u2009nm and 297\u2009nm, respectively. The submitted technique was validated in accordance with ICH Q2 R1 guidelines and the linearity of the standard calibration curve was observed over the concentration range of 10\u2013500\u2009ng\/ml for DPZ and 20\u20131,000\u2009ng\/ml for TRZ. The detection limits (LOD) were found to be 2.65 and 5.4\u00a0ng\/ml, and the limits of quantitation (LOQ) were 8.05 and 16.3\u00a0ng\/ml for DPZ and TRZ, respectively. This technique was used further to quantify the studied medications in their laboratory\u2010prepared mixtures, commercial tablets and spiked plasma samples. The results obtained were not significantly different from those acquired from the comparison methods, indicating the high accuracy and precision of the proposed method. Furthermore, the ecological friendliness of the suggested method was evaluated and proven to be excellent using Green Analytical Procedure Index (GAPI) and Analytical GREEnness (AGREE) evaluation tools.<\/jats:p>","DOI":"10.1002\/bio.4797","type":"journal-article","created":{"date-parts":[[2024,6,4]],"date-time":"2024-06-04T23:59:17Z","timestamp":1717545557000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["A green micelle\u2010enhanced first derivative synchronous fluorescence approach for determination of donepezil HCl and trazodone HCl in their pure state, pharmaceutical dosage form and spiked human plasma"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-6577-3499","authenticated-orcid":false,"given":"Mennah M.","family":"Abd El wahab","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Faculty of Pharmacy Sinai University \u2010 Arish Branch  Arish Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samar","family":"Saad","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy Mansoura University  Mansoura Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeinab A.","family":"Sheribah","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy Mansoura University  Mansoura Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nahed","family":"El\u2010Enany","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy Mansoura University  Mansoura Egypt"},{"name":"Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy New Mansoura University  New Mansoura Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,4]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-30400-w"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-13194-1"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1098\/rsos.210354"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.saa.2020.119239"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-26827-2"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.saa.2023.123029"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/bio.4586"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/bio.4635"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.microc.2020.105207"},{"key":"e_1_2_9_11_1","unstructured":"National Center for Biotechnology Information. (2023)PubChem Compound Summary for CID 5533 Trazodone. PubChem.https:\/\/pubchem.ncbi.nlm.nih.gov\/compound\/Trazodone(accessed June 20 2023)."},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0004-282X2011000100010"},{"key":"e_1_2_9_13_1","volume-title":"Trazodone","author":"Shin J.J.","year":"2024"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharma.2019.02.003"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.4067\/S0717-97072014000200002"},{"key":"e_1_2_9_16_1","first-page":"5","volume":"29","author":"Abdelraoof A.","year":"2017","journal-title":"Int. J. Sci."},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0731-7085(02)00327-8"},{"key":"e_1_2_9_18_1","unstructured":"National Center for Biotechnology Information. 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