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Synchronous fluorescence of tripelennamine hydrochloride and diphenhydramine was determined using \u0394\u03bb\u2009=\u200960\u2009nm. The first derivative of synchronous fluorescence was computed to resolve overlap in the synchronous fluorescence spectra. Tripelennamine hydrochloride was quantified at 375\u2009nm, whereas diphenhydramine was quantified at 293\u2009nm; each is the zero\u2010crossing point of the other. As diphenhydramine exhibited weak native fluorescence, micelle enhancement upon incorporation of sodium dodecyl sulfate was considered. Two\u2010level full factorial design was carried out to optimize experimental parameters. Optimum conditions involved using SDS (2% w\/v) along with Teorell and Stenhagen buffer (pH\u00a09). The method was found to be linear over the range 0.2\u20134.5 and 0.2\u20135\u00a0\u03bcg\/mL for tripelennamine and diphenhydramine, respectively, with limits of detection 0.211 and 0.159\u2009\u03bcg\/mL. The method was successfully applied for simultaneous determination of tripelennamine hydrochloride and diphenhydramine in laboratory\u2010prepared gel containing all possible excipients with mean percent recoveries \u00b1SD 100.59\u2009\u00b1\u00a00.79 and 98.99\u2009\u00b1\u00a00.98 for tripelennamine hydrochloride and diphenhydramine, respectively. The proposed method was proved to be eco\u2010friendly using different greenness assessment tools.<\/jats:p>","DOI":"10.1002\/bio.4815","type":"journal-article","created":{"date-parts":[[2024,7,7]],"date-time":"2024-07-07T22:44:13Z","timestamp":1720392253000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Green micellar factorial design optimized first derivative synchronous spectrofluorimetric method for tripelennamine and diphenhydramine determination in pharmaceutical gel"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5548-8742","authenticated-orcid":false,"given":"Mona M.","family":"Amer","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy Tanta University, The Medical Campus of Tanta University  Tanta Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Basma Z.","family":"El\u2010Khateeb","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy Tanta University, The Medical Campus of Tanta University  Tanta Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,7,7]]},"reference":[{"volume-title":"Clarke's analysis of drugs and poisons","year":"2011","author":"AC W. 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