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The N, S\u2010CQDs were prepared through a microwave\u2010assisted method in 30\u2009s. The resulting N, S\u2010CQDs were characterized using transmission electron microscopy (TEM), high\u2010resolution transmission electron microscopy (HRTEM), Fourier transform infrared spectroscopy (FTIR), and X\u2010ray photoelectron spectroscopy (XPS). They exhibit fluorescence emission at 460\u2009nm after excitation at 385\u2009nm with a high quantum yield (60%). The analytical approach for VON determination relies on the quenching effect exerted by VON on the native fluorescence intensity of CQDs. The quenching mechanism was investigated using Stern\u2013Volmer plots. The proposed method demonstrates linearity across a concentration range 10\u201380\u2009\u03bcM (4.6\u201336.8\u00a0\u03bcg\/mL) with corresponding limits of detection and quantitation calculated as 2.17\u2009\u03bcM (0.99\u2009\u03bcg\/mL) and 6.58\u2009\u03bcM (3.02\u2009\u03bcg\/mL), respectively. The method has been effectively utilized for the determination of VON in the pharmaceutical samples. Statistical comparison with reported RP\u2010HPLC has been performed to verify the accuracy and precision of the developed method. The environmental sustainability of the developed method has been thoroughly examined through various greenness metrics.<\/jats:p>","DOI":"10.1002\/bio.4834","type":"journal-article","created":{"date-parts":[[2024,7,22]],"date-time":"2024-07-22T06:42:14Z","timestamp":1721630534000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Fluorimetric determination of Vonoprazan via quenching of nitrogen and sulfur co\u2010doped carbon quantum dots: A rapid and sustainable analytical approach"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7905-2062","authenticated-orcid":false,"given":"Aya","family":"Barseem","sequence":"first","affiliation":[{"name":"Pharmaceutical Analysis Department, Faculty of Pharmacy Menofia University  Menofia Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6030-3829","authenticated-orcid":false,"given":"Mahmoud","family":"Elshahawy","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy Tanta University  Tanta Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samar H.","family":"Elagamy","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy Tanta University  Tanta Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,22]]},"reference":[{"key":"e_1_2_10_2_1","author":"National Center for Biotechnology Information","journal-title":"PubChem"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.2147\/CEG.S228352"},{"key":"e_1_2_10_4_1","first-page":"145","volume":"67","author":"Alzaghal N. 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