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The proposed technique relied on the implementation of a first derivative synchronous fluorescence spectroscopy for the determination of the investigated drugs simultaneously without pretreatment procedures. The synchronous fluorescence of both drugs was measured in methanol at \u0394\u03bb of 100\u2009nm, and the first derivative peak amplitudes (<jats:sup>1<\/jats:sup>D) were measured at 321\u2009nm for ATN and 348\u2009nm for LSR, each at the zero\u2010crossing point of the other. The method was rectilinear over the concentration ranges of 100\u20131000\u2009ng\/mL and 50\u2013500\u2009ng\/mL for ATN and LSR, respectively. The proposed technique was successfully applied for the determination of the studied drugs in their laboratory\u2010prepared mixture and pharmaceutical formulations, demonstrating high mean recoveries of 100.54% for ATN and 100.62% for LSR, without interference from common excipients. The results were in good agreement with those obtained by the comparison method. Three recent greenness assessment tools, the Eco\u2010Scale tool, the Green Analytical Procedure Index (GAPI) metric, and the Analytical GREEnness metric approach, were employed to affirm the greenness of the proposed method. The developed method was proven to be eco\u2010friendly.<\/jats:p>","DOI":"10.1002\/bio.4839","type":"journal-article","created":{"date-parts":[[2024,7,26]],"date-time":"2024-07-26T10:31:40Z","timestamp":1721989900000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Eco\u2010friendly simultaneous estimation of atenolol and losartan potassium in spiked human plasma via synchronous fluorescence with sustainability assessment"],"prefix":"10.1002","volume":"39","author":[{"given":"Ekram A.","family":"Ghozzy","sequence":"first","affiliation":[{"name":"Pharmaceutical Chemistry Department, Faculty of Pharmacy Delta University for Science and Technology  Gamasa Egypt"},{"name":"Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy Mansoura University  Mansoura Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nahed M.","family":"El\u2010Enany","sequence":"additional","affiliation":[{"name":"Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy Mansoura University  Mansoura Egypt"},{"name":"Pharmaceutical Chemistry Department, Faculty of Pharmacy New Mansoura University  New Mansoura Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7968-6487","authenticated-orcid":false,"given":"Manar M.","family":"Tolba","sequence":"additional","affiliation":[{"name":"Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy Mansoura University  Mansoura Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9022-2632","authenticated-orcid":false,"given":"Samah Abo","family":"El Abass","sequence":"additional","affiliation":[{"name":"Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy Mansoura University  Mansoura Egypt"},{"name":"Pharmaceutical Chemistry Department, College of Pharmacy Prince Sattam Bin Abdulaziz University  Al\u2010Kharj Kingdom of Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,7,26]]},"reference":[{"volume-title":"Principles of Instrumental Analysis","year":"2017","author":"Skoog D. 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