{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T14:39:40Z","timestamp":1792075180945,"version":"4.4.0"},"reference-count":28,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T00:00:00Z","timestamp":1727654400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T00:00:00Z","timestamp":1727654400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Luminescence"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>As a gamma amino butyric acid\u2010ergic agonist, Baclofen is often prescribed to adults and children for the treatment of severe spasticity that originates in the brain or spinal cord. Even after reviewing the literature extensively, no one has documented a method for estimating baclofen using microwave\u2010assisted stability\u2010indicating spectrofluorimetric techniques, despite the abundance of options for baclofen stability, assay, and bioanalysis. Organic solvents, which are typically necessary for current procedures but may be costly and toxic, have a severe effect on aquatic life and the environment. Using green solvents and 4\u2010chloro\u20107\u2010nitrobezofuran as a fluorescent probe, this work conducted a stability\u2010indicating spectrofluorimetric estimate of baclofen. Through the use of a design\u2010of\u2010experiments technique, a reliable microwave\u2010aided spectrofluorimetric method was developed, with little solvent consumption and time for sample analysis. Prior to conducting response surface analysis and optimizing important variables and responses, a fractional factorial design was used to screen method variables and responses. A central composite design was then employed for these purposes. This flexible spectrofluorimetric technique was used to assess baclofen concentrations in forced degraded samples and marketed formulations. For baclofen determination, the suggested spectrofluorimetric approach was found to be green, quick, easy to use, economical, and user\u2010friendly.<\/jats:p>","DOI":"10.1002\/bio.4911","type":"journal-article","created":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T01:44:43Z","timestamp":1727747083000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Whiteness, redness, blueness and greenness profile assessment and design of experiments approach to microwave\u2010aided sensitive and green spectrofluorophotometric determination of baclofen"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5282-2087","authenticated-orcid":false,"given":"Pintu","family":"Prajapati","sequence":"first","affiliation":[{"name":"Department of Quality Assurance Maliba Pharmacy College  Maliba Campus, Bardoli\u2010Mahuva Road, Tarsadi, Mahuva Surat Gujarat India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ankita","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Quality Assurance Maliba Pharmacy College  Maliba Campus, Bardoli\u2010Mahuva Road, Tarsadi, Mahuva Surat Gujarat India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vilas","family":"Surana","sequence":"additional","affiliation":[{"name":"Department of Quality Assurance Maliba Pharmacy College  Maliba Campus, Bardoli\u2010Mahuva Road, Tarsadi, Mahuva Surat Gujarat India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veera Shakar","family":"Pulusu","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry Ohio University  Athens Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anzarul","family":"Haque","sequence":"additional","affiliation":[{"name":"Central Laboratories Unit Qatar University  Doha Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohd Abul","family":"Kalam","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, College of Pharmacy, P.O. Box \u2013 2457 King Saud University  Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shailesh","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Quality Assurance Maliba Pharmacy College  Maliba Campus, Bardoli\u2010Mahuva Road, Tarsadi, Mahuva Surat Gujarat India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,30]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trac.2021.116223"},{"key":"e_1_2_11_3_1","first-page":"1","volume-title":"Q3C (R6) guideline, Impurities: a Guideline for Residual Solvent","author":"International Council for Harmonization","year":"2016"},{"key":"e_1_2_11_4_1","first-page":"987","volume-title":"Volume I, Residual Solvents, the Indian Pharmacopeia Commission","author":"Indian Pharmacopoeia","year":"2018"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40508-016-0051-z"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.5937\/arhfarm73-43479"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/jaoacint\/qsad108"},{"key":"e_1_2_11_8_1","first-page":"1","volume":"054","author":"Shahi A.","year":"2023","journal-title":"J. Chromatogr. Sci."},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/jaoacint\/qsad082"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/jaoacint\/qsad052"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.202300139"},{"key":"e_1_2_11_12_1","unstructured":"Drug Data Bank of Baclofen https:\/\/go.drugbank.com\/drugs\/DB00181 accessed on date 14thOctober 2023."},{"issue":"1","key":"e_1_2_11_13_1","first-page":"522","volume":"22","author":"Hosseinimehr S. J.","year":"2010","journal-title":"Asian J. Chem."},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.saa.2006.09.039"},{"issue":"1","key":"e_1_2_11_15_1","first-page":"17","volume":"20","author":"Fadhil G.","year":"2017","journal-title":"Al\u2010Nahrain J. 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Pharmtech res."},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9673(95)00944-2"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.24297\/jac.v8i1.4035"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.saa.2020.119165"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1080\/05704928.2011.557121"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/bio.3640"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1039\/AN9851000881"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1039\/an9901501559"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1039\/AN9952000373"}],"container-title":["Luminescence"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bio.4911","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/bio.4911","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bio.4911","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T11:00:25Z","timestamp":1775818825000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/bio.4911"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,30]]},"references-count":28,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["10.1002\/bio.4911"],"URL":"https:\/\/doi.org\/10.1002\/bio.4911","archive":["Portico"],"relation":{},"ISSN":["1522-7235","1522-7243"],"issn-type":[{"value":"1522-7235","type":"print"},{"value":"1522-7243","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,30]]},"assertion":[{"value":"2024-07-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e4911"}}