{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,5]],"date-time":"2026-07-05T04:14:26Z","timestamp":1783224866863,"version":"3.54.6"},"reference-count":25,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,11,11]],"date-time":"2024-11-11T00:00:00Z","timestamp":1731283200000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Luminescence"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>This study focuses on developing novel antimicrobials to combat drug\u2010resistant pathogens, addressing compounds failing clinical trials due to inadequate physicochemical properties. Sixteen imidazolidine\u20104\u2010one derivatives were synthesized by extensive evaluation using molecular docking, absorption, distribution, metabolism, excretion (ADME) predictions, and antimicrobial testing. Molecular docking studies conducted with Schr\u00f6dinger's Glide revealed that compounds S4 and G8 exhibited superior docking scores of \u22127.839 and \u22127.776, respectively. The G series outperformed the S series in scores. ADME analysis confirmed all compounds adhered to Lipinski's rule of five. In addition, IR and NMR provided details about the structure of the compounds. Antimicrobial activity was assessed against <jats:styled-content style=\"fixed-case\"><jats:italic>Escherichia coli<\/jats:italic><\/jats:styled-content>, <jats:styled-content style=\"fixed-case\"><jats:italic>Staphylococcus aureus<\/jats:italic><\/jats:styled-content>, and <jats:styled-content style=\"fixed-case\"><jats:italic>Candida albicans<\/jats:italic><\/jats:styled-content>, with compounds G2 and S2 showing exceptional minimum inhibitory concentration (MIC) values of 6.25\u2009\u03bcg\/mL against <jats:styled-content style=\"fixed-case\"><jats:italic>E. coli<\/jats:italic><\/jats:styled-content>. S2 also demonstrated impressive activity against <jats:styled-content style=\"fixed-case\"><jats:italic>S. aureus<\/jats:italic><\/jats:styled-content> (MIC 3.12\u2009\u03bcg\/mL), and S4 exhibited potent activity against <jats:styled-content style=\"fixed-case\"><jats:italic>C. albicans<\/jats:italic><\/jats:styled-content> (MIC 0.8\u2009\u03bcg\/mL) than fluconazole (1.6\u2009\u03bcg\/mL). Additionally, antihelmintic activity was evaluated, with G1, G3, G8, S2, S4, S7, and S8 showing effective paralysis and death time 20\u2009min and below at 50\u2009mg\/mL concentration. These results underscore the potential of new imidazolidine\u20104\u2010one derivatives as suitable sources to develop a drug candidate to treat resistant infections.<\/jats:p>","DOI":"10.1002\/bio.70026","type":"journal-article","created":{"date-parts":[[2024,11,11]],"date-time":"2024-11-11T23:59:16Z","timestamp":1731369556000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Schiff Base Mediated Synthesis of Novel Imidazolidine\u20104\u2010One Derivatives for Potential Antimicrobial and Anthelmintic Activities"],"prefix":"10.1002","volume":"39","author":[{"given":"Naresh\u00a0Babu","family":"Chilamakuru","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Chemistry Raghavendra Institute of Pharmaceutical Education and Research (RIPER) \u2010 Autonomous  Anantapur Andhra Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Triveni","family":"Singirisetty","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry Raghavendra Institute of Pharmaceutical Education and Research (RIPER) \u2010 Autonomous  Anantapur Andhra Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anoop","family":"Bodapati","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences Vignan's Foundation for Science Technology &amp; Research (Deemed to be University)  Vadlamudi Andhra Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sudha\u00a0Divya\u00a0Madhuri","family":"Kallam","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences Vignan's Foundation for Science Technology &amp; Research (Deemed to be University)  Vadlamudi Andhra Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1423-2502","authenticated-orcid":false,"given":"Vinod\u00a0Kumar","family":"Nelson","sequence":"additional","affiliation":[{"name":"Center for Global Health Research Saveetha Medical College, and Hospitals Saveetha Institute of Medical and Technical Sciences  Chennai Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Punna\u00a0Rao","family":"Suryadevara","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy Lincoln University College  Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3500-8681","authenticated-orcid":false,"given":"Selvankumar","family":"Thangaswamy","sequence":"additional","affiliation":[{"name":"Center for Global Health Research Saveetha Medical College, and Hospitals Saveetha Institute of Medical and Technical Sciences  Chennai Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,11]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.281.1.61"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsps.2015.02.008"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28020838"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-16-8399-2_6"},{"key":"e_1_2_9_6_1","volume-title":"Vogel's Textbook of Practical Organic Chemistry","author":"Vogel A. 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