{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T06:02:00Z","timestamp":1773381720180,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T00:00:00Z","timestamp":1740355200000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Luminescence"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Four benzothiazole\u2010thiazolidine\u20104\u2010one derivatives <jats:bold>6<\/jats:bold> and <jats:bold>7a\u2013c<\/jats:bold> were prepared, and their chemical constructions were proved by IR, NMR, UV\u2013Vis absorption, and emission spectra. The absorption spectra of the synthesized derivatives showed that extending the conjugated system through the insertion of a substituted benzylidene group led to a red shift of \u03bb<jats:sub>max<\/jats:sub>, where the nitro derivative <jats:bold>7c<\/jats:bold> displayed the longer wavelength. Likewise, the emission spectra presented the same effect, where the Stock shift displayed a reversed order in which the parent <jats:bold>6<\/jats:bold> has the highest value. The synthesized derivatives exhibited cytotoxic effectiveness against several tumor cell lines, where compound <jats:bold>7b<\/jats:bold> displayed significant cytotoxicity towards MCF\u20107 cells (IC<jats:sub>50<\/jats:sub>\u2009=\u20098.73\u2009\u00b1\u20090.41\u2009\u03bcM). The in\u00a0vitro VEGFR\u20102 kinase inhibitory activity of synthetic benzothiazole\u2010thiazolidin\u20104\u2010one derivatives has been assessed, where derivative <jats:bold>7c<\/jats:bold> had the strongest inhibition (IC<jats:sub>50<\/jats:sub>\u2009=\u20090.20\u2009\u00b1\u20090.10\u2009\u03bcM), followed by derivatives <jats:bold>7b<\/jats:bold> and <jats:bold>7a<\/jats:bold>, respectively. However, the molecular docking showed that derivatives <jats:bold>7b<\/jats:bold> and <jats:bold>7c<\/jats:bold> have higher binding affinity than Sorafenib due to unique molecular interactions with target residues. Moreover, the pharmacokinetic parameters of the newly synthesized derivatives showed that derivative <jats:bold>7b<\/jats:bold> revealed moderate lipophilicity and a lack of Lipinski violations, making it a viable lead contender.<\/jats:p>","DOI":"10.1002\/bio.70125","type":"journal-article","created":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T00:52:59Z","timestamp":1740531179000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Synthesis of Novel Donor\u2010\u03c0\u2010Acceptor Benzothiazole\u2010Thiazolidinone Fluorescent Chromophores With Enhanced Biological Activity"],"prefix":"10.1002","volume":"40","author":[{"given":"Haifa","family":"Alharbi","sequence":"first","affiliation":[{"name":"Department of Chemistry, College of Science Northern Border University  Arar Saudi 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