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The sensing behavior of receptors was demonstrated by UV\u2013vis and fluorescence experiments, and naked\u2010eye detection exhibited prominent visual emission color change toward Cu<jats:sup>2+<\/jats:sup>\/Cl<jats:sup>\u2212<\/jats:sup> and Fe<jats:sup>3+<\/jats:sup> over other testing cations\/anions in DMSO:water (9:1, \u03bd\/v) solution. The 1:1 binding stoichiometry was confirmed by Job's plot, FT\u2010IR, mass spectral titration, and also DFT studies with target ions as evidence for the binding nature of <jats:bold>OXPH(ANQ)<\/jats:bold>\/<jats:bold>OXPID(ANQ)<\/jats:bold> with Cu<jats:sup>2+<\/jats:sup>\/Cl<jats:sup>\u2212<\/jats:sup> and Fe<jats:sup>3+<\/jats:sup> ions, respectively. Limits of detection for <jats:bold>OXPH(ANQ)<\/jats:bold> with Cu<jats:sup>2+<\/jats:sup>\/Cl<jats:sup>\u2212<\/jats:sup> ions were of 4.50 and 4.91\u2009\u03bcM, and <jats:bold>OXPID(ANQ)<\/jats:bold> with Fe<jats:sup>3+<\/jats:sup> ions were of 5.06\u2009\u03bcM. Interestingly, chemosensors <jats:bold>OXPH(ANQ)<\/jats:bold>\/<jats:bold>OXPID(ANQ)<\/jats:bold> applied to intracellular image of Cu<jats:sup>2+<\/jats:sup>\/Cl<jats:sup>\u2212<\/jats:sup> and Fe<jats:sup>3+<\/jats:sup> ions in living cells of HepG2 (Liver cancer cells) via confocal fluorescence microscopy technique at physiological environmental and also utilized for antimicrobial activity.<\/jats:p>","DOI":"10.1002\/bio.70137","type":"journal-article","created":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T03:19:15Z","timestamp":1741749555000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Isoquinoline\u2010Fused Benzimidazoles Based Highly Selective Fluorogenic Receptors for Detection of Cu<sup>2+<\/sup>, Fe<sup>3+<\/sup>, and Cl<sup>\u2212<\/sup> Ions: Cytotoxicity and HepG2 Cancer Cell 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