{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T12:44:59Z","timestamp":1793191499072,"version":"4.5.0"},"reference-count":53,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T00:00:00Z","timestamp":1743984000000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Luminescence"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/common-cold\">COVI<\/jats:ext-link>\n                    D\u201019\u20102024 is one of the most frequently occurring illnesses worldwide. One of the symptoms of COVID\u201019 is sever cough. This study presents a novel first derivative synchronous spectrofluorimetric method that is rapid, highly sensitive, cost\u2010effective, and environmentally safe for determining two coformulated anticough drugs, dextromethorphan and guaifenesin, simultaneously. At 281.5 and 297.4\u2009nm, respectively, the fluorescence of guaifenesin and dextromethorphan was measured. The dilution solvent was methanol, and the wavelength difference (\u0394\u03bb) was 20\u2009nm. The method verified good linearity (\n                    <jats:italic>r<\/jats:italic>\n                    \u2009&gt;\u20090.999) for both dextromethorphan (10.0\u2013200.0\u2009ng\u2009mL\n                    <jats:sup>\u22121<\/jats:sup>\n                    ) and guaifenesin (30.0\u2013800.0\u2009ng\u2009mL\n                    <jats:sup>\u22121<\/jats:sup>\n                    ) within the intended concentration ranges. The findings showed that the suggested method had a high degree of sensitivity, with detection limits for guaifenesin and dextromethorphan being 8.64 and 1.81\u2009ng\u2009mL\n                    <jats:sup>\u22121<\/jats:sup>\n                    , respectively. For both analytes, the intraday and interday precisions were less than 0.81% RSD. With low percentage RSD values and high percentage recoveries, the developed method was successfully used to estimate the aforementioned medications in dosage forms and human plasma samples simultaneously. The CACI tool evaluated the method's economy, usefulness, and applicability, whereas MoGAPI and AGREE metrics verified its exceptional eco\u2010friendliness and greenness. The procedure was thoroughly verified in compliance with ICH Q2 (R2) standards.\n                  <\/jats:p>","DOI":"10.1002\/bio.70165","type":"journal-article","created":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T21:08:38Z","timestamp":1744060118000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Ultrasensitive First Derivative Synchronous Spectrofluorimetric Approach for the Concurrent Quantification of COVID\u201019\u20102024 Treatment Combination Dextromethorphan and Guaifenesin in Different Matrices: Compliance With Greenness and Practicality Metrics"],"prefix":"10.1002","volume":"40","author":[{"given":"Amal\u00a0Abdullah","family":"Alrashidi","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Sciences, College of Pharmacy Princess Nourah Bint Abdulrahman University  Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4429-6504","authenticated-orcid":false,"given":"Mohamed\u00a0M.","family":"Salim","sequence":"additional","affiliation":[{"name":"Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy Mansoura University  Mansoura Egypt"},{"name":"Department of Pharmaceutical Chemistry, Faculty of Pharmacy Horus University\u2010Egypt  New Damietta Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sitah","family":"Alharthi","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, College of Pharmacy Shaqra University, Al\u2010Dawadmi Campus  Al\u2010Dawadmi Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4479-7723","authenticated-orcid":false,"given":"Aya\u00a0Saad","family":"Radwan","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Faculty of Pharmacy Horus University\u2010Egypt  New Damietta Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,7]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiph.2024.03.001"},{"key":"e_1_2_8_3_1","first-page":"1","article-title":"Cough Management: A Practical Approach","volume":"7","author":"Blasio F.","year":"2011","journal-title":"Journal Cough"},{"key":"e_1_2_8_4_1","unstructured":"National Center for Biotechnology Information \u201cPubChem Compound Summary for CID 5464025 \u201d accessed January 28 2025 Dextromethorphan Hydrobromide https:\/\/pubchem.ncbi.nlm.nih.gov\/compound\/Tussade."},{"issue":"9","key":"e_1_2_8_5_1","first-page":"1137","article-title":"Pharmacology, Antitussive Efficacy of Dextromethorphan in Cough Associated With Acute Upper Respiratory Tract Infection","volume":"52","author":"Lee P.","year":"2000","journal-title":"Journal of 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