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The HPMC\u2010AuNPs@1 system was synthesized by functionalizing gold nanoparticles (AuNPs) with hydroxypropyl methylcellulose (HPMC) and loading Compound 1 into the system. The resulting nanocarrier exhibited a typical aggregation\u2010induced emission (AIE) effect in aqueous media, showing strong green fluorescence in a DMSO\u2010H\n                    <jats:sub>2<\/jats:sub>\n                    O (5:95) solution. Host\u2010guest sensing experiments revealed that HPMC\u2010AuNPs@1 demonstrated high selectivity for detecting carcinoembryonic antigen (CEA) among 14 different metallic ions and antigen molecules. A noticeable fluorescence shift occurred upon binding with CEA, and the detection limit for CEA was as low as 2.56\u2009\u00d7\u200910\n                    <jats:sup>\u22126<\/jats:sup>\n                    \u2009M. Additionally, we explored the potential therapeutic applications of HPMC\u2010AuNPs@1 in cancer treatment, particularly in inducing pyroptosis, a form of programmed cell death. In\u00a0vitro experiments with SNU\u201016 cells showed that HPMC\u2010AuNPs@1 nanoparticles inhibited cancer cell proliferation by inducing pyroptosis. These findings suggest that HPMC\u2010AuNPs@1 holds great promise as a therapeutic platform for cancer treatment, particularly in targeting cell proliferation pathways via pyroptosis induction.\n                  <\/jats:p>","DOI":"10.1002\/bio.70235","type":"journal-article","created":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T18:34:52Z","timestamp":1749839692000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Polysaccharide\u2010Based Fluorescent Polymer Carrier for Natural Product Delivery and Gastric Cancer Inhibition"],"prefix":"10.1002","volume":"40","author":[{"given":"Minghan","family":"Bai","sequence":"first","affiliation":[{"name":"Department of Oncology Fourth Affiliated Hospital of Harbin Medical University  Harbin Heilongjiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yupeng","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of General 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