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This study presents the green synthesis of silver nanoparticles (Ag\u2010NPs) using <jats:styled-content style=\"fixed-case\"><jats:italic>Aerva lanata<\/jats:italic><\/jats:styled-content> flower extract and evaluates their larvicidal efficacy against <jats:italic>Cx. quinquefasciatus<\/jats:italic>, <jats:italic>An. stephensi<\/jats:italic>, and <jats:italic>Ae. aegypti<\/jats:italic>. The biosynthesized Ag\u2010NPs, characterized by UV\u2013Vis, FT\u2010IR, XRD, SEM\u2013EDX, TEM, Zeta potential, and DLS analyses, exhibited potent larvicidal and pupicidal activities, with LC<jats:sub>50<\/jats:sub> values of 6.501, 20.875, and 22.649\u2009ppm, respectively. The morphological and histopathological alterations in treated larvae, alongside significant modulation of antioxidant (SOD, GPx) and detoxification (GST, AChE) enzymes, indicate oxidative stress as a key mode of action. Importantly, biosafety tests revealed minimal toxicity to <jats:styled-content style=\"fixed-case\"><jats:italic>Artemia salina<\/jats:italic><\/jats:styled-content>, highlighting the eco\u2010compatibility of these Ag\u2010NPs. This study demonstrates an innovative, plant\u2010based nanobiopesticide with strong potential for sustainable mosquito control, addressing the challenges of insecticide resistance and environmental toxicity.<\/jats:p>","DOI":"10.1002\/bio.70266","type":"journal-article","created":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T11:00:02Z","timestamp":1753268402000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Eco\u2010Friendly Synthesis of Silver Nanoparticles and Its Larvicidal Property Against Malaria, Filariasis, and Dengue Vectors"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5165-4272","authenticated-orcid":false,"given":"Krishnan","family":"Raguvaran","sequence":"first","affiliation":[{"name":"Research Centre for Pharmaceutical Ingredients and Traditional Medicine, National Research and Innovation Agency (BRIN), Kompleks Puspitek Serpong  South Tangerang Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manickam","family":"Kalpana","sequence":"additional","affiliation":[{"name":"Entomology Laboratory, Department of Zoology Periyar University  Salem Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Palanisamy","family":"Devapriya","sequence":"additional","affiliation":[{"name":"Entomology Laboratory, Department of Zoology Periyar University  Salem Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suresh","family":"Kalaivani","sequence":"additional","affiliation":[{"name":"Entomology Laboratory, Department of Zoology Periyar University  Salem Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marissa","family":"Angelina","sequence":"additional","affiliation":[{"name":"Research Centre for Pharmaceutical Ingredients and Traditional Medicine, National Research and Innovation Agency (BRIN), Kompleks Puspitek Serpong  South Tangerang Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fransiska\u00a0Sri\u00a0Herwahyu","family":"Krismastuti","sequence":"additional","affiliation":[{"name":"Research Center for Chemistry, National Research and Innovation Agency (BRIN), Kompleks Puspitek, Serpong  South Tangerang Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1856-7681","authenticated-orcid":false,"given":"Akhtar","family":"Rasool","sequence":"additional","affiliation":[{"name":"Research Center for Chemistry, National Research and Innovation Agency (BRIN), Kompleks Puspitek, Serpong  South Tangerang Indonesia"},{"name":"Department of Biotechnology Manav Rachna International Institute of Research and Studies  Faridabad Haryana India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajan","family":"Maheswaran","sequence":"additional","affiliation":[{"name":"Entomology Laboratory, Department of Zoology Periyar University  Salem Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,23]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s41182-016-0010-0"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-022-12571-9"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2018.12.012"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2024.141171"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/insects13020162"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202411432"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultsonch.2018.10.022"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biotechadv.2008.09.002"},{"key":"e_1_2_11_10_1","first-page":"202","article-title":"Phytochemical Screening and Antimicrobial Activities of \n                     Aerva lanata","volume":"204","author":"Sundararajan M.","year":"2017","journal-title":"Journal of Ethnopharmacology"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11356-015-4586-4"},{"key":"e_1_2_11_12_1","unstructured":"WHO \u201cGuidelines for Laboratory and Field Testing of Mosquito Larvicides (2005)."},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/jee\/18.2.265a"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(76)90527-3"},{"key":"e_1_2_11_15_1","first-page":"1117","article-title":"Superoxide\u2010Driven Oxidation of Quercetin and a Simple Sensitive Assay for Determination of Superoxide Dismutase","volume":"19","author":"Kostyuk V. 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