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It depends on the synthesis of highly fluorescent carbon dots (\u03bbex\/em 350.0\u2013430.0\u2009nm) using a one\u2010step microwave\u2010assisted carbonization method. Characterization of the formed carbon dots was performed using transmission electron microscopy (TEM), Fourier transform infrared (FTIR), Zeta potential analysis, fluorescence spectroscopy UV\u2013Visible spectroscopy, and X\u2010ray photoelectron spectroscopy (XPS). The formed carbon dots appeared to be spherical in shape, with a 2.0\u2010 to 3.5\u2010nm average particle size. The synthesized carbon dots were used for the determination of tinidazole by static fluorescence quenching mechanism and inner filter effect. The quenching effect on the synthesized carbon dots' fluorescence signal was utilized for the determination of tinidazole in pure form in concentration samples (2.0\u201330\u2009\u03bcM) with a %recovery of 99.86\u2009\u00b1\u20091.38 in pure form, 100.0\u2009\u00b1\u20091.67 in tablet and 99.56\u2009\u00b1\u20094.18 in urine. The validity of the method was assessed according to the recommendations of the International Conference on Harmonization. The greenness of the method was evaluated using different greenness assessment tools. The proposed probe is eco\u2010friendly due to using water as the only solvent in the absence of other organic solvents.<\/jats:p>","DOI":"10.1002\/bio.70349","type":"journal-article","created":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T12:30:58Z","timestamp":1762777858000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Nature\u2010Driven N,S\u2010Highly Fluorescent Carbon Dots as Turn\u2010Off Fluorescent Nanosensors for Determination of Tinidazole in Pharmaceutical Dosage Form and in Biological Fluid"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-5820-574X","authenticated-orcid":false,"given":"Ahmed\u00a0A.","family":"Shokeer","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy Mansoura University  Mansoura Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fawzia\u00a0A.","family":"Ibrahim","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy Mansoura University  Mansoura Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4741-7298","authenticated-orcid":false,"given":"Nora\u00a0A.","family":"Abdallah","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy Mansoura University  Mansoura Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,10]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultsonch.2024.107056"},{"key":"e_1_2_7_3_1","first-page":"75","volume-title":"J Med Libr Assoc","author":"Wisher D.","year":"2012"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rechem.2024.101788"},{"key":"e_1_2_7_5_1","article-title":"Green Synthesis of Highly Luminescent Carbon Quantum Dots From Lemon Juice","volume":"1","author":"Hoan B. 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