{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T05:54:08Z","timestamp":1764050048064,"version":"3.45.0"},"reference-count":22,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T00:00:00Z","timestamp":1762992000000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009392","name":"Prince Sattam bin Abdulaziz University","doi-asserted-by":"publisher","award":["PSAU\/2025\/R\/1446"],"award-info":[{"award-number":["PSAU\/2025\/R\/1446"]}],"id":[{"id":"10.13039\/100009392","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Luminescence"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    This study presents a sustainable analytical methodology for the simultaneous quantification of the antiemetic drug meclizine (MCZ) and its potentially teratogenic impurity 4\u2010chlorobenzophenone (BZP) using first derivative synchronous fluorescence spectroscopy (FDSFS). The method employs a \u0394\n                    <jats:italic>\u03bb<\/jats:italic>\n                    of 40\u2009nm followed by first derivatization, enabling the selective determination of MCZ at 275\u2009nm and BZP at 311\u2009nm. Given the clinical importance of MCZ in managing nausea and vomiting during pregnancy (affecting 70%\u201380% of expectant mothers) and the documented reproductive toxicity of the BZP impurity (capable of crossing the placenta and disrupting fetal development), this method addresses a critical safety concern in pharmaceutical quality control. BZP has been linked to adverse reproductive outcomes, hormonal disruption, and developmental toxicity in animal and human studies, making its detection alongside the parent drug imperative for maternal\u2013fetal safety. The practicality and sustainability were quantitatively assessed using the Blue Applicability Grade Index (BAGI), achieving a remarkable score of 80\/100, confirming its superior applicability in routine pharmaceutical analysis. This eco\u2010friendly, sensitive, and selective analytical approach represents a significant advancement in the impurity profiling of meclizine used during pregnancy, offering a sustainable tool for pharmaceutical quality assurance with direct implications for maternal and fetal health protection.\n                  <\/jats:p>","DOI":"10.1002\/bio.70360","type":"journal-article","created":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T16:19:18Z","timestamp":1763050758000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["BAGI\u2010Validated First Derivative Synchronous Fluorescence Spectroscopy for Sustainable Impurity Profiling of Meclizine: Clinical Implications for Maternal\u2013Fetal Safety"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9073-9903","authenticated-orcid":false,"given":"Samah\u00a0Abo","family":"El\u00a0Abass","sequence":"first","affiliation":[{"name":"Pharmaceutical Chemistry Department, College of Pharmacy Prince Sattam Bin\u2010Abdul Aziz University  Al\u2010Kharj Kingdom of Saudi Arabia"},{"name":"Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy Mansoura University  Mansoura Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdulmalik\u00a0S.\u00a0A.","family":"Altamimi","sequence":"additional","affiliation":[{"name":"Pharmaceutical Chemistry Department, College of Pharmacy Prince Sattam Bin\u2010Abdul Aziz University  Al\u2010Kharj Kingdom of Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taibah","family":"Aldakhil","sequence":"additional","affiliation":[{"name":"Pharmaceutical Chemistry Department, College of Pharmacy Prince Sattam Bin\u2010Abdul Aziz University  Al\u2010Kharj Kingdom of Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"El\u00a0Sherbiny","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Faculty of Pharmacy Nile Valley University Egypt  Fayoum Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1352-0297","authenticated-orcid":false,"given":"Mary\u00a0E.\u00a0K.","family":"Wahba","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Faculty of Pharmacy Delta University for Science and Technology  Gamasa Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed\u00a0E.","family":"Draz","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Faculty of Pharmacy Delta University for Science and Technology  Gamasa Egypt"},{"name":"Department of Pharmaceutical Chemistry, College of Pharmacy Almaaqal University  Basra Iraq"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,13]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gtc.2011.03.009"},{"key":"e_1_2_8_3_1","unstructured":"USP.NF USP \u201cMeclizine Hydrochloride \u201d in Rockville MD USA (2021)."},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-35380-5"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2018.11.190"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reprotox.2017.08.015"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdrb.21137"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2016.04.037"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1530\/EC-17-0375"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/bmc.5353"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28207044"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.icarus.2021.114689"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac00285a036"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac50025a010"},{"key":"e_1_2_8_15_1","first-page":"1","article-title":"Materials Sustainability in the Pharmaceutical Industry","volume":"1","author":"Bhadoriya A.","year":"2024","journal-title":"Sustainability & Circularity NOW"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3GC02347H"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scp.2024.101493"},{"volume-title":"Organic Medicinal and Pharmaceutical Chemistry","year":"2010","author":"Beale J. 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