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The proposed method is based on the formation of a highly yellow fluorescent derivative through the reaction of the studied drug with acetylacetone and formaldehyde in an acetate buffer (pH\u20094.5), yielding a strong emission at 485\u2009nm following excitation at 415\u2009nm. The experimental variables that affected the one\u2010pot synthesis were investigated and optimized. The calibration curve demonstrated a linear relationship over a concentration range of 0.2\u20132.0\u2009\u03bcg\/mL, with low detection and quantitation limits of 0.03 and 0.09\u2009\u03bcg\/mL, respectively. The designed method was validated following the ICH guidelines, permitting precise analysis of the studied drug in its tablets and human plasma samples with high recovery. Furthermore, the environmental sustainability of the suggested method was assessed using contemporary tools for greenness, whiteness, and blueness evaluation. The results demonstrated that the method possesses excellent eco\u2010friendly characteristics, highlighting its strong alignment with the principles of green analytical chemistry.<\/jats:p>","DOI":"10.1002\/bio.70380","type":"journal-article","created":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T05:33:09Z","timestamp":1765517589000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["First Spectrofluorimetric Method for Sensitive Determination of Armodafinil in Dosage Forms and Human Plasma: Greenness, Blueness, and Whiteness Assessment"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-7464-083X","authenticated-orcid":false,"given":"Mohamed\u00a0A.","family":"Saeed","sequence":"first","affiliation":[{"name":"Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy Fayoum University  Faiyum Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2400-1177","authenticated-orcid":false,"given":"Noha\u00a0S.","family":"Mostafa","sequence":"additional","affiliation":[{"name":"Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy Cairo University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7804-6442","authenticated-orcid":false,"given":"Amr\u00a0M.","family":"Mahmoud","sequence":"additional","affiliation":[{"name":"Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy Cairo University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6011-1306","authenticated-orcid":false,"given":"Abobakr\u00a0A.","family":"Mohamed","sequence":"additional","affiliation":[{"name":"Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy Fayoum University  Faiyum Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2673-3301","authenticated-orcid":false,"given":"Mohamed\u00a0Ahmed","family":"Elsayed","sequence":"additional","affiliation":[{"name":"Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy Fayoum University  Faiyum Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,11]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1301534"},{"key":"e_1_2_10_3_1","first-page":"11","article-title":"Analytical Method Development and Validation of Armodafinil: A Concise Review","volume":"2","author":"Jain P.","year":"2023","journal-title":"Quantum Journal of Medical and Health Sciences"},{"key":"e_1_2_10_4_1","article-title":"Modafinil","volume":"15","author":"Castaner J.","year":"1990","journal-title":"Drugs of the Future"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-200342020-00002"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsmc.2013.04.002"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1092852900018460"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1526-4637.2003.03014.x"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.351"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1461145713001612"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.2174\/1570159X22666240131121642"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.22159\/ijcpr.2017v9i5.22162"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.talanta.2007.03.057"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.2174\/157341212801619298"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.200700545"},{"key":"e_1_2_10_16_1","article-title":"Intrinsic Stability Study of Armodafinil Hydrochloride by Forced Degradation and Impurity Profiling","volume":"7","author":"Jain D.","year":"2016","journal-title":"Pharmaceutica Analytica Acta"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/bmc.4342"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.5530\/jyp.2018.10.13"},{"key":"e_1_2_10_19_1","first-page":"604","article-title":"Stability Indicating RP HPLC Method for the Estimation Armodafinil in Tablet Dosage Form","volume":"6","author":"Sagar P. 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