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In recent years, the development of high\u2010efficiency, high\u2010sensitivity fluorescent probes has garnered significant attention due to their advantages in spatial and temporal resolution, minimal background interference, and capacity for deep tissue imaging. These characteristics have positioned fluorescent probes as essential tools for elucidating the dynamic distribution and underlying mechanisms of H\n                    <jats:sub>2<\/jats:sub>\n                    S activity. This review systematically examines recent progress in near\u2010infrared fluorescent probes, particularly those based on nucleophilic substitution, reduction reactions, and copper sulfide precipitation. The discussion emphasizes innovations in detection mechanisms, performance enhancements, and applications in biological systems. These advancements provide a theoretical foundation for a deeper understanding of H\n                    <jats:sub>2<\/jats:sub>\n                    S biology and support the development of integrated diagnosis and treatment tools, thereby advancing the application of H\n                    <jats:sub>2<\/jats:sub>\n                    S probes in life sciences, environmental monitoring, and clinical translation.\n                  <\/jats:p>","DOI":"10.1002\/bio.70435","type":"journal-article","created":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T12:36:27Z","timestamp":1770122187000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Multimodal Hydrogen Sulfide Fluorescent Probes: Mechanistic Advances, Bioimaging Challenges, and Prospects for Clinical Translation"],"prefix":"10.1002","volume":"41","author":[{"given":"Chimiao","family":"Wang","sequence":"first","affiliation":[{"name":"Laboratory of Pharmacy and 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