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The structural modification of moving the recognition site and extending the\n                    <jats:italic>meta<\/jats:italic>\n                    \u2010group was performed. The normoxia and hypoxia conditions did not affect the absorption and fluorescence variation during the response of\n                    <jats:bold>BIENBD\u2010GSH<\/jats:bold>\n                    to GSH.\n                    <jats:bold>BIENBD\u2010GSH<\/jats:bold>\n                    exhibited a dose\u2010dependent response to the GSH level to report the fluorescence signal at 500\u2009nm under the excitation of 365\u2009nm. The structural modification introduced the advantages of higher synthetic yield and emission red\u2010shift, with the retention of a wide linear interval and relatively high sensitivity. Other advantages of\n                    <jats:bold>BIENBD\u2010GSH<\/jats:bold>\n                    included stable performance in various working conditions, high selectivity towards GSH, and low cytotoxicity upon living pulmonary cells.\n                    <jats:bold>BIENBD\u2010GSH<\/jats:bold>\n                    achieved monitoring the intracellular GSH level, while for the hypoxia\u2010related situations, both the post hoc recovery and prior dexmedetomidine protection were visualized. This work provided some useful information on the pathological processes in clinical operations and the nursing schedules.\n                  <\/jats:p>","DOI":"10.1002\/bio.70479","type":"journal-article","created":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T23:54:35Z","timestamp":1775606075000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Monitoring Hypoxic Alleviation With Dexmedetomidine Protection via Glutathione Detection by a Benzo\u2010Imidazole\u2010Derived Fluorescent Probe"],"prefix":"10.1002","volume":"41","author":[{"given":"Linhui","family":"Weng","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Affiliated Jinhua Hospital Zhejiang University School of Medicine  Jinhua China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanliang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Affiliated Jinhua Hospital Zhejiang University School of Medicine  Jinhua China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-1342-8705","authenticated-orcid":false,"given":"Zhongquan","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Affiliated Jinhua Hospital Zhejiang University School of Medicine  Jinhua China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junfeng","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Affiliated Jinhua Hospital Zhejiang University School of Medicine  Jinhua China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-2931-9437","authenticated-orcid":false,"given":"Yujin","family":"Liu","sequence":"additional","affiliation":[{"name":"Nursing Department The Second Hospital of Jinhua  Jinhua China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,4,7]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.2174\/156652409788167087"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000002288"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000005525"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1530\/REP-20-0267"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12871-024-02737-w"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/ACO.0000000000001341"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12013-013-9659-8"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/ACO.0000000000000143"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/86.1.38"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-023-02615-y"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.21037\/atm.2018.04.29"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/MS9.0000000000003500"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm13082354"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.22456\/1679-9216.99755"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/resp.13430"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s44211-024-00659-8"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s44211-025-00721-z"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.saa.2024.125107"},{"key":"e_1_2_9_20_1","first-page":"169","article-title":"N\u2010Acetyl Cysteine and Glutathione in Health and Cancer\u2010Pharmacogenomics, Research, and Clinical Practice: Hypothesis and Review","volume":"28","author":"Morales\u2010Borges R. 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