{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T06:43:10Z","timestamp":1777272190959,"version":"3.51.4"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T00:00:00Z","timestamp":1776124800000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Luminescence"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Epstein\u2013Barr virus (EBV), a widespread human \u03b3\u2010herpesvirus, is associated with infectious mononucleosis and several malignancies, posing a major public health challenge. Acyclovir (ACV), the first\u2010line antiviral drug, is limited by poor solubility, short half\u2010life, and low bioavailability. To overcome these drawbacks, we designed a hyaluronic acid\u2013based nanocarrier modified with microbial extracts and a fluorescent small molecule (1\u2010HA\u20102), and constructed an ACV\u2010loaded nanosystem (1\u2010HA\u20102@ACV) with improved drug loading, fluorescence responsiveness, and aqueous stability, enabling both therapeutic delivery and ion sensing. Notably, 1\u2010HA\u20102@ACV allows sensitive detection of Na\n                    <jats:sup>+<\/jats:sup>\n                    and PO\n                    <jats:sub>4<\/jats:sub>\n                    <jats:sup>3\u2212<\/jats:sup>\n                    , two clinically relevant ions whose dysregulation is closely linked to EBV\u2010associated disease progression, drug safety, and therapeutic monitoring. In EBV\u2010susceptible cells, EBV infection markedly increased EBNA1 and sTREM\u20101 expression, whereas treatment with 1\u2010HA\u20102@ACV significantly inhibited viral replication and reduced sTREM\u20101 overexpression more effectively than free ACV, while blank nanoparticles showed no effect. These findings suggest that 1\u2010HA\u20102@ACV not only enhances the therapeutic efficacy of ACV but also provides a dual\u2010function platform for EBV\u2010targeted therapy and real\u2010time monitoring through modulation of sTREM\u20101 pathways and ion\u2010associated biomarkers.\n                  <\/jats:p>","DOI":"10.1002\/bio.70480","type":"journal-article","created":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T05:36:28Z","timestamp":1776231388000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Microbial\u2010Engineered Fluorescent Nanocarrier for Ion Ratiometric Sensing and sTREM\u20101\u2010Mediated EBV Inhibition"],"prefix":"10.1002","volume":"41","author":[{"given":"Mingliang","family":"Chen","sequence":"first","affiliation":[{"name":"Research and Translational Laboratory of Acute Injury and Secondary Infection, Department of Laboratory Medicine Minhang Hospital, Fudan University  Shanghai 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