{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T06:43:13Z","timestamp":1777272193081,"version":"3.51.4"},"reference-count":88,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,19]],"date-time":"2026-04-19T00:00:00Z","timestamp":1776556800000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Luminescence"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Perovskite quantum dots (PQDs) have emerged as highly promising luminescent materials for sensitive and selective detection of heavy metal ions, particularly Cu\n                    <jats:sup>2+<\/jats:sup>\n                    , owing to their exceptional photophysical properties, defect\u2010tolerant structures, and tunable surface chemistry. However, their practical implementation remains limited by intrinsic instability, environmental sensitivity, and incomplete mechanistic understanding. This review provides a design\u2010driven framework that integrates fundamental principles, advanced engineering strategies, and mechanistic insights essential for developing next\u2010generation PQD\u2010based luminescent sensors. Key aspects discussed include the evolution of synthesis routes, the impact of surface defects and ligand dynamics on optical response, and the roles of encapsulation, compositional tuning, polymeric confinement, and MOF\u2010based architectures in overcoming moisture, oxygen, and thermal degradation pathways. Signal transduction mechanisms such as electron transfer, FRET, ratiometric emission, and aggregation\u2010induced modulation are critically analyzed with emphasis on their relevance to Cu\n                    <jats:sup>2+<\/jats:sup>\n                    sensing performance. By summarizing analytical metrics, stability barriers, and emerging hybrid platforms, this review highlights strategic directions for achieving high\u2010performance, reproducible, and durable PQD sensors. The insights presented establish a foundation for rational design and application\u2010oriented development of luminescent PQD\u2010based Cu\n                    <jats:sup>2+<\/jats:sup>\n                    detection technologies.\n                  <\/jats:p>","DOI":"10.1002\/bio.70485","type":"journal-article","created":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T05:48:36Z","timestamp":1776664116000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Perovskite Quantum Dot\u2013Based Luminescent Sensors for Cu\n                    <sup>2+<\/sup>\n                    Detection: Stability Engineering and Performance Across Aqueous, Organic, and Confined Media"],"prefix":"10.1002","volume":"41","author":[{"given":"Mohamed\u00a0Abu","family":"Shuheil","sequence":"first","affiliation":[{"name":"Faculty of Allied Medical Sciences, Hourani Center for Applied Scientific Research Al\u2010Ahliyya Amman University  Amman Jordan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"PadmaPriya","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry, School of Sciences JAIN (Deemed to be University)  Bangalore Karnataka India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Subhashree","family":"Ray","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, IMS and SUM Hospital Siksha \u2018O\u2019 Anusandhan (Deemed to be University)  Bhubaneswar Odisha India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Talal\u00a0Aziz","family":"Qassem","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory Technics, College of Health and Medical Technology Alnoor University  Mosul Iraq"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gunjan","family":"Garg","sequence":"additional","affiliation":[{"name":"Centre for Research Impact &amp; 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