{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T02:03:31Z","timestamp":1779761011378,"version":"3.53.1"},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T00:00:00Z","timestamp":1778716800000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Luminescence"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Hydrogen sulfide (H\n                    <jats:sub>2<\/jats:sub>\n                    S) is a newly\u2010recognized gaseous signaling molecule and participates in a range of physiological and pathological processes. In this work, based on a molecular switch coupling an imine group with an adjacent H\u2010bond, we designed \u201cturn\u2010on\u201d aggregation\u2010induced emission (AIE)\u2010active fluorescent probes for H\n                    <jats:sub>2<\/jats:sub>\n                    S detection, designated as TSI series. To evaluate the substituents and electron effects on the molecular switch as well as H\n                    <jats:sub>2<\/jats:sub>\n                    S response, four TSI compounds bearing different substituents (HTSI, DFTSI, DPTSI, and DOTSI) were synthesized and compared in the performance of H\n                    <jats:sub>2<\/jats:sub>\n                    S sensing. Among all the probes, DPTSI achieves the best sensing performance toward H\n                    <jats:sub>2<\/jats:sub>\n                    S (&gt;\u2009tenfold fluorescence enhancement). Building on these findings, a rational design strategy involving H\u2010bond protection\/deprotection and electron\u2010donating group modifications can be employed for developing other probes based on the TSI platform. In further glioblastoma cell imaging assessments, DPTSI effectively lighted up glioblastoma cells with high contrast due to their elevated H\n                    <jats:sub>2<\/jats:sub>\n                    S levels, suggesting its potential as a practical tool for biological H\n                    <jats:sub>2<\/jats:sub>\n                    S sensing and glioma cell mapping in\u00a0vivo.\n                  <\/jats:p>","DOI":"10.1002\/bio.70506","type":"journal-article","created":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T08:15:59Z","timestamp":1778746559000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["AIE\u2010Active Fluorescence \u201cTurn\u2010on\u201d Bioprobes Mediated by Intramolecular Hydrogen\u2010Bonding for Sensitive Detection of H\n                    <sub>2<\/sub>\n                    S and Visualization in U87 Cells"],"prefix":"10.1002","volume":"41","author":[{"given":"Zebin","family":"Fang","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, the First affiliated Hospital, School of Medicine Zhejiang University  Hangzhou Zhejiang People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxiang","family":"Weng","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, the First affiliated Hospital, School of Medicine Zhejiang University  Hangzhou Zhejiang People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4301-7676","authenticated-orcid":false,"given":"Kaiyuan","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, the First affiliated Hospital, School of Medicine Zhejiang University  Hangzhou Zhejiang People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, the First affiliated Hospital, School of Medicine Zhejiang University  Hangzhou Zhejiang People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weijian","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, the First affiliated Hospital, School of Medicine Zhejiang University  Hangzhou Zhejiang People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, the First affiliated Hospital, School of Medicine Zhejiang University  Hangzhou Zhejiang People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luyuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, the First affiliated Hospital, School of Medicine Zhejiang University  Hangzhou Zhejiang People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianxiang","family":"Zhan","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, the First affiliated Hospital, School of Medicine Zhejiang University  Hangzhou Zhejiang People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0619-6257","authenticated-orcid":false,"given":"Renya","family":"Zhan","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, the First affiliated Hospital, School of Medicine Zhejiang University  Hangzhou Zhejiang People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianbo","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, the First affiliated Hospital, School of Medicine Zhejiang 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