{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T08:01:46Z","timestamp":1785225706566,"version":"3.55.0"},"reference-count":32,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:00:00Z","timestamp":1782777600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:00:00Z","timestamp":1782777600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Luminescence"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The role of two different non\u2010steroidal anti\u2010inflammatory drugs, namely, mefenamic acid (MA) (2\u2010[(2,3\u2010dimethylphenyl)amino]benzoic acid) and aceclofenac (ACF) (2\u2010[(2,6\u2010dichlorophenyl)amino]phenyl acetoxyacetic acid), and their electrostatic interactions with bovine serum albumin (BSA) and adenine model systems have been studied. The binding affinity for drug formation depends primarily on the heterocyclic ring and functional groups. The hydrophobic interactions were also evaluated. The spectral properties of the interactions were investigated by UV\u2013visible, fluorescence, FT\u2010IR, cyclic voltammetry and molecular modelling methods. In addition, the Stern\u2013Volmer plots for BSA and adenine with the drug molecules are shown. Moreover, the static quenching interaction, the binding constant (\n                    <jats:italic>K<\/jats:italic>\n                    <jats:sub>a<\/jats:sub>\n                    ) and the number of sites (\n                    <jats:italic>n<\/jats:italic>\n                    ) have been determined. The binding efficiency is evaluated and compared on the basis of its\n                    <jats:italic>E<\/jats:italic>\n                    value. The free energy, van der Waals and hydrogen\u2010bonding interaction values of BSA with the drugs are determined. In order to assess the electrochemical process, the scan rate is another important parameter, which has been determined by using cyclic voltammograms.\n                  <\/jats:p>","DOI":"10.1002\/bio.70541","type":"journal-article","created":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T18:53:19Z","timestamp":1782845599000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Spectral, Electrochemical and Molecular Docking Studies Over Effects of Interaction Between Two Different NSAIDs With BSA and DNA Base"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7781-0632","authenticated-orcid":false,"given":"J.","family":"Thulasidhasan","sequence":"first","affiliation":[{"name":"Department of Chemistry V.S.B. Engineering College  Karur Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9985-4484","authenticated-orcid":false,"given":"P. S. Syed","family":"Ibrahim","sequence":"additional","affiliation":[{"name":"Department of Science and Humanities Dhanalakshmi College of Engineering  Chennai Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Rajendiran","sequence":"additional","affiliation":[{"name":"Department of Chemistry Annamalai University  Annamalai Nagar Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,30]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/bcp.70101"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.12628"},{"key":"e_1_2_10_4_1","first-page":"55","article-title":"Simultaneous Determination of Mefenamic Acid and Paracetamol From Combined Dosage Forms by Spectrophotometry","volume":"63","author":"Dhake A. S.","year":"2001","journal-title":"Indian Journal of Pharmaceutical Sciences"},{"key":"e_1_2_10_5_1","first-page":"5075","article-title":"Simultaneous Spectrophotometric Estimation of Aceclofenac and Paracetamol","volume":"19","author":"Nikam A. D.","year":"2007","journal-title":"Asian Journal of Chemistry"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.4c01306"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/07391102.2018.1509731"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/1758-2946-1-15"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-987X(199604)17:5\/6<490::AID-JCC1>3.0.CO;2-P"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-987X(19981115)19:14<1639::AID-JCC10>3.0.CO;2-B"},{"key":"e_1_2_10_11_1","first-page":"111","article-title":"Interaction of Fast Garnet GBC With Bovine Serum Albumin: Spectral,Electrochemical and Molecular Docking Methods","volume":"8","author":"Thulasidhasan J.","year":"2018","journal-title":"International Journal of Innovative Research and Studies"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0RA09580J"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9RA05549E"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-65053-6"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.saa.2020.118803"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molliq.2020.113695"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphotobiol.2020.111917"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0TB00818D"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26216728"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.saa.2020.118063"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jlumin.2010.12.016"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2004.11.062"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2005.04.032"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2008.01.023"},{"key":"e_1_2_10_25_1","first-page":"93","volume-title":"Modern Quantum Chemistry","author":"F\u00f6rster T.","year":"1996"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1386-1425(02)00362-1"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2003.10.018"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1520-6343(1998)4:2<93::AID-BSPY2>3.0.CO;2-T"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1006\/abio.1996.0369"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/136287"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13065-023-00944-z"},{"key":"e_1_2_10_32_1","first-page":"135","article-title":"Voltametric and Molecular Docking Investigations of Ferrocenylmethylaniline and Its N\u2010Acetylated Derivative Interacting With DNA","volume":"14","author":"Yahiaoui A.","year":"2024","journal-title":"Journal of Electrochemical Science and Engineering"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.5599\/jese.2738"}],"container-title":["Luminescence"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bio.70541","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/bio.70541","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bio.70541","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T07:35:24Z","timestamp":1785224124000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/bio.70541"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,30]]},"references-count":32,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1002\/bio.70541"],"URL":"https:\/\/doi.org\/10.1002\/bio.70541","archive":["Portico"],"relation":{},"ISSN":["1522-7235","1522-7243"],"issn-type":[{"value":"1522-7235","type":"print"},{"value":"1522-7243","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,30]]},"assertion":[{"value":"2025-08-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70541"}}