{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T08:01:28Z","timestamp":1785225688416,"version":"3.55.0"},"reference-count":60,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:00:00Z","timestamp":1782777600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:00:00Z","timestamp":1782777600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Luminescence"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>This work introduces a novel, green switch on\u2013off spectrofluorimetric quenching method using erythrosine B (EB) for nano\u2010trace determination of pentoxifylline (PTX) or donepezil HCl (DPZ) in tablets and spiked plasma, enabling rapid clinical monitoring. The suggested approach relies on the quenching effect of either DPZ or PTX on the intrinsic fluorescence of EB, various experimental conditions influencing fluorescence quenching were investigated and optimized. An ion pair complex is formed between the cationic amino group in either drugs and the anionic phenolic group of EB at mild acidic conditions using Britton\u2013Robinson buffer. After excitation at 528\u2009nm, the fluorescence quenching intensities were measured linearly at 552\u2009nm across the range (50\u20131000\u2009ng\/mL) for PTX with quantification limits of 16.76\u2009ng\/mL and over the range (20\u2013500\u2009ng\/mL) for DPZ with limit of quantification 17.56\u2009ng\/mL for DPZ. The suggested method exhibited high % recoveries, confirming its reliable applicability in complicated matrices. The validation of the suggested methodology was further performed in accordance with the International Conference of Harmonization (ICH Q2R2) recommendations. Furthermore, the method's greenness, blueness and whiteness profiles was investigated, revealing its remarkable sustainability.<\/jats:p>","DOI":"10.1002\/bio.70542","type":"journal-article","created":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T22:28:41Z","timestamp":1782858521000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Sustainable Spectrofluorimetric Quenching Approach for Determination of Pentoxifylline or Donepezil HCl via Complexation With Erythrosine B: Application to Tablets and Human Plasma"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-6577-3499","authenticated-orcid":false,"given":"Mennah M. Abd","family":"El wahab","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy Sinai University \u2010 Arish branch  Arish Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samar","family":"Saad","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy Mansoura University  Mansoura Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nahed","family":"El\u2010Enany","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy Mansoura University  Mansoura Egypt"},{"name":"Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy New Mansoura University  New Mansoura Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeinab A.","family":"Sheribah","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy Mansoura University  Mansoura Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,30]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cogsc.2021.100508"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpha.2024.101013"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.5535\/arm.22027"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ardp.202200398"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25245789"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm14186611"},{"key":"e_1_2_14_8_1","unstructured":"National Center for Biotechnology Information \u201cPubChem Compound Summary for CID 4740 \u201d Pentoxifylline PubChem accessed January 26 2026 https:\/\/pubchem.ncbi.nlm.nih.gov\/compound\/Pentoxifylline."},{"key":"e_1_2_14_9_1","volume-title":"StatPearls","author":"Annamaraju P.","year":"2024"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/openhrt-2015-000365"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.4236\/ajac.2016.72015"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/jaoacint\/qsad097"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioelechem.2011.06.008"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtice.2019.11.011"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40097-019-0295-8"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13065-025-01531-0"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11250-018-1710-8"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.1515\/gps-2024-0139"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.54.1026"},{"key":"e_1_2_14_20_1","unstructured":"National Center for Biotechnology Information \u201cPubChem Compound Summary for CID 3152 \u201d Donepezil PubChem accessed January 26 2026 https:\/\/pubchem.ncbi.nlm.nih.gov\/compound\/Donepezil."},{"key":"e_1_2_14_21_1","first-page":"117","volume-title":"Profiles of Drug Substances, Excipients and Related Methodology","author":"Asiri Y. 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