{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T08:01:30Z","timestamp":1785225690014,"version":"3.55.0"},"reference-count":42,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Luminescence"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    A novel, sustainable spectrofluorimetric method was developed for memantine determination using erythrosin B as a fluorescent probe, addressing critical analytical gaps in pharmaceutical quality control and environmental monitoring. The method exploits static fluorescence quenching through ground\u2010state complex formation between protonated memantine and anionic erythrosin B. Initially, UV\u2013Vis absorption spectroscopy revealed a significant hypochromic effect accompanied by a hypsochromic shift of 5\u2009nm, with the absorption maximum shifting from 527 to 522\u2009nm upon complex formation, while fluorescence studies demonstrated concentration\u2010dependent quenching at 527\u2009nm excitation and 553\u2009nm emission wavelengths. Subsequently, temperature\u2010dependent Stern\u2013Volmer analysis yielded quenching constants decreasing from 6.22\u2009\u00d7\u200910\n                    <jats:sup>5<\/jats:sup>\n                    to 4.47\u2009\u00d7\u200910\n                    <jats:sup>5<\/jats:sup>\n                    \u2009mol\u2009L\n                    <jats:sup>\u22121<\/jats:sup>\n                    (298\u2013313\u2009K), confirming the static quenching mechanism. Furthermore, Job's method established 2:1 memantine\u2010to\u2010erythrosin B stoichiometry, which was validated by quantum mechanical calculations revealing energetically favorable binding interactions. The developed method exhibited excellent analytical performance with a linear range of 0.02\u20132.0\u2009\u03bcg\/mL, a detection limit of 6.5\u2009ng\/mL, precision (%RSD &lt;\u20092%), and accuracy (98.59%). Moreover, successful applications included pharmaceutical formulations and spiked environmental water samples, achieving quantitative recoveries ranging from 96% to 104% across different matrices. Finally, a comprehensive sustainability assessment demonstrated superior green credentials compared to conventional chromatographic approaches.\n                  <\/jats:p>","DOI":"10.1002\/bio.70563","type":"journal-article","created":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T00:36:22Z","timestamp":1782952582000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Novel Green Spectrofluorimetric Approach for Memantine Quantification With Mechanistic Elucidation Through Quantum Mechanical Modeling and Green Analytical Chemistry Evaluation"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-1525-2473","authenticated-orcid":false,"given":"Muneef M.","family":"Aldhafeeri","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratories Sciences College of Applied Medical Sciences, University of Hafr AlBatin  Hafr AlBatin Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,1]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12877-018-0857-5"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/YIC.0000000000000032"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/etc.3339"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1155\/2024\/5538398"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/etc.1879"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2012.01.003"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph17091162"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4347(99)00157-7"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.3797\/scipharm.1310-09"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.3797\/scipharm.1008-17"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.201000579"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2006.10.045"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/101249"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/jms.303"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.talanta.2025.128442"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.microc.2025.114560"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/bio.1119"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.optmat.2022.112486"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.saa.2015.02.051"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.saa.2012.03.031"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.saa.2025.126000"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.saa.2024.125342"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1039\/D5RA02737C"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1039\/D5RA00519A"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.microc.2025.114515"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1039\/D5RA03551A"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/bio.4358"},{"key":"e_1_2_9_29_1","first-page":"2073","article-title":"Utility of the Food Colorant Erythrosine B as an Effective Green Probe for Quantitation of the Anticancer Sunitinib","volume":"38","author":"El Sharkasy M. 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