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The probe sensitively and selectively detected both N\n                    <jats:sub>2<\/jats:sub>\n                    H\n                    <jats:sub>4<\/jats:sub>\n                    and pH, with the salicylaldehyde group as the sensing site. Based on the combined AIE\/ESIPT mechanism, the probe exhibited a yellow\u2010green turn\u2010on fluorescent response to N\n                    <jats:sub>2<\/jats:sub>\n                    H\n                    <jats:sub>4<\/jats:sub>\n                    with a low detection limit of 26\u2009nM and a rapid detection time of 10\u2009min. Through the ICT process, the probe displayed a light blue turn\u2010on fluorescence signal for neutral pH variations in a linear range of 5.0\u20137.8 with a p\n                    <jats:italic>K<\/jats:italic>\n                    <jats:sub>a<\/jats:sub>\n                    value of 6.26. The microstructural attributes of the probe during assembly could elucidate the recognition processes. Probe\n                    <jats:bold>CASA<\/jats:bold>\n                    enabled quantitative analysis of N\n                    <jats:sub>2<\/jats:sub>\n                    H\n                    <jats:sub>4<\/jats:sub>\n                    and pH in real environmental samples. A smartphone\u2010assisted sensing system and probe\u2010coated portable test strips were developed to facilitate convenient and on\u2010site testing. Additionally, the probe possessed excellent biocompatibility and low cytotoxicity, making it possible to monitor the changes of N\n                    <jats:sub>2<\/jats:sub>\n                    H\n                    <jats:sub>4<\/jats:sub>\n                    and pH within living cells. This dual\u2010channel N\n                    <jats:sub>2<\/jats:sub>\n                    H\n                    <jats:sub>4<\/jats:sub>\n                    \u2010pH independent detection can prevent spectral crosstalk, facilitate instrument simplification, and provide a more intelligent and reliable analytical toolkit for complex systems. The findings are anticipated to provide more innovative strategies of highly efficient fluorescent probes for multi\u2010analyte detection.\n                  <\/jats:p>","DOI":"10.1002\/bio.70571","type":"journal-article","created":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T05:38:01Z","timestamp":1784093881000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Bifunctional Bile Acid\u2010Salicylaldehyde Based Fluorescent Probe for Excellent Detection of Hydrazine and pH, and Multiple Applications in Environmental Samples, Smartphone\u2010Assisted System, Paper Strips, and Living Cells"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8830-0646","authenticated-orcid":false,"given":"Zhen","family":"Zhang","sequence":"first","affiliation":[{"name":"School of Chemistry Xi'an Jiaotong University  Xi'an 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