{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T06:37:34Z","timestamp":1793083054747,"version":"4.5.0"},"reference-count":42,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T00:00:00Z","timestamp":1790380800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T00:00:00Z","timestamp":1790380800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Luminescence"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Ferric reducing antioxidant power (FRAP) is a well\u2010established antioxidant in\u00a0vitro assay. This work introduces an innovative FRAP\u2010analog assay based on green\u2010synthesized carbon dots (GCDs) for the sensitive evaluation of antioxidant activity. The GCDs were prepared via ordinary roasting of sweet potato, which is considered a natural and renewable precursor, yielding highly fluorescent (quantum yield 53%), water\u2010soluble CDs with excellent ferric (Fe\n                    <jats:sup>3+<\/jats:sup>\n                    ) complexing activity. In this system, the addition of Fe\n                    <jats:sup>3+<\/jats:sup>\n                    leads to quenching of the fluorescence of GCDs. Antioxidant\u2010induced reduction of Fe\n                    <jats:sup>3+<\/jats:sup>\n                    to Fe\n                    <jats:sup>2+<\/jats:sup>\n                    leads to a measurable turn on effect. Using ascorbic acid as a reference antioxidant, the sensor exhibited a linear response between 2 and 14\u2009\u03bcg\/mL (\n                    <jats:italic>R<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    0.996) with a limit of detection of 0.82\u2009\u03bcg\/mL,\u00a0very good accuracy (recovery\u2009=\u2009103.27%\u2009\u00b1\u20093.48%) and acceptable precision (RSD\u2009=\u20091.01%\u20135.61%). The developed assay was applied successfully to pharmaceutical products and plant extracts. The GCD\u2010based FRAP analog demonstrated strong correlation with traditional FRAP assays. The devised approach eliminated the use of toxic nonrenewable reagents, rendering it excellent green on both analytical Eco\u2010scale, Analytical GREEnness (AGREE),\u00a0and Nano Eco\u2010Scale metrics. This green, nanomaterial\u2010based approach provides a promising alternative for antioxidants' analysis in food and pharmaceuticals.\n                  <\/jats:p>","DOI":"10.1002\/bio.70628","type":"journal-article","created":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T07:56:58Z","timestamp":1790409418000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Biomass\u2010Derived Carbon Dots\u2013Based FRAP Analog for Sensitive Evaluation of Antioxidant Activity: Application to Pharmaceutical Products and Plant Extracts"],"prefix":"10.1002","volume":"41","author":[{"given":"Nermeen","family":"El\u2010Hefnawy","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy Tanta University  Tanta Egypt"},{"name":"Department of Pharmaceutical Chemistry, Faculty of Pharmacy Al\u2010Salam University  Tanta 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