{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T06:41:14Z","timestamp":1792478474361,"version":"4.5.0"},"reference-count":34,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T00:00:00Z","timestamp":1791676800000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Luminescence"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    A vinyl\u2010functionalized tetraphenylethylene derivative (OA\u2010TPE) with aggregation\u2010induced emission (AIE) was synthesized and incorporated into a poly(ethylene glycol) diacrylate (PEGDA) hydrogel by photopolymerization. OA\u2010TPE emission increased with medium viscosity (log\u2013log linear regression,\n                    <jats:italic>R<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    \u2009=\u20090.9861). A 21\u2009wt% PEGDA hydrogel containing 2\u2010\u03bcM OA\u2010TPE supported the proliferation of encapsulated L929 mouse fibroblasts over 10\u2009days. Between Day 1 and Day 10, the storage modulus (G\u2032) decreased from approximately 3638 to 2379\u2009Pa, the loss modulus (G\u2033) decreased from approximately 177 to 73\u2009Pa, and fluorescence intensity decreased from 6237 to 4365\u2009a.u. Fluorescence intensity was linearly associated with G\u2032 and G\u2033 (\n                    <jats:italic>R<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    \u2009=\u20090.9878 and 0.9890, respectively). These data establish a proof\u2010of\u2010concept relationship among cell growth, hydrogel mechanics, and AIE emission in 3D culture. The method is indirect: A 10\u2010day cell\u2010free stability control, matrix\u2010specific DNA recovery, and interference by pH, reactive oxygen species, or metabolites were not independently quantified, so the fluorescence decrease should not yet be interpreted as a cell\u2010specific or fully quantitative proliferation signal.\n                  <\/jats:p>","DOI":"10.1002\/bio.70637","type":"journal-article","created":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T04:59:05Z","timestamp":1791781145000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Sensing Cell Proliferation in 3D Culture With a Luminescent Hydrogel"],"prefix":"10.1002","volume":"41","author":[{"given":"Haiying","family":"Wang","sequence":"first","affiliation":[{"name":"The Second Affiliated Hospital of Xinjiang Medical University  Urumqi Xinjiang Uygur Autonomous Region P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fenghua","family":"Ma","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital of Xinjiang Medical University  Urumqi Xinjiang Uygur Autonomous Region P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhilong","family":"Zhang","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital of Xinjiang Medical University  Urumqi Xinjiang Uygur Autonomous Region P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xierzhati","family":"Ahemaitijiang","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital of Xinjiang Medical University  Urumqi Xinjiang Uygur Autonomous Region P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-3939-2596","authenticated-orcid":false,"given":"Abulimiti","family":"Amuti","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital of Xinjiang Medical University  Urumqi Xinjiang Uygur Autonomous Region P. R. 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