{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T17:38:47Z","timestamp":1792604327503,"version":"4.5.0"},"reference-count":84,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Luminescence"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Hydrophilic perovskite quantum dots (PQDs) have emerged as promising materials for biomedical diagnostics due to their exceptional optical tunability and high photoluminescence quantum yield. However, their instability, toxicity, and degradation in aqueous and biological environments remain critical barriers to practical applications. This review integrates predictive modeling and bioinspired stabilization strategies to provide a comprehensive understanding of the mechanisms governing PQD instability and the design of robust, biocompatible nanostructures. Multiscale computational approaches\u2014including density functional theory, molecular dynamics, and machine learning\u2014are analyzed to elucidate degradation pathways and forecast material performance under physiological conditions. In parallel, bioinspired and hybrid stabilization strategies, such as ligand engineering, polymer\/silica encapsulations, and adaptive coating design, are critically evaluated for enhancing aqueous stability and biosafety. The stabilized PQDs are further discussed in multiplexed biomedical diagnostics, highlighting their potential for precision sensing of multiple biomarkers. This is the comprehensive review that bridges predictive modeling with bioinspired stabilization to advance hydrophilic PQDs toward intelligent and multiplexed diagnostic platforms.<\/jats:p>","DOI":"10.1002\/bio.70639","type":"journal-article","created":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T07:45:11Z","timestamp":1791359111000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Predictive Modeling and Bioinspired Strategies for Stabilizing Hydrophilic Perovskite Quantum Dots in Multiplexed Biomedical Diagnostics"],"prefix":"10.1002","volume":"41","author":[{"given":"Mohamed Abu","family":"Shuheil","sequence":"first","affiliation":[{"name":"Faculty of Allied Medical Sciences, Hourani Center for Applied Scientific Research Al\u2010Ahliyya Amman University  Amman Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Aldulaimi","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy Al\u2010Zahrawi University  Karbala Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subhashree","family":"Ray","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, IMS and SUM Hospital Siksha 'O' Anusandhan (Deemed to be University)  Odisha India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Talal Aziz","family":"Qassem","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory Technics, College of Health and Medical Technology Alnoor University  Mosul Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunjan","family":"Garg","sequence":"additional","affiliation":[{"name":"Centre for Research Impact &amp; Outcome, Chitkara University Institute of Engineering and Technology Chitkara University  Rajpura India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renu","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University Institute of Sciences Chandigarh University  Mohali India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dilbar","family":"Urazbaeva","sequence":"additional","affiliation":[{"name":"Department of Psychology and Medicine Mamun university  Khiva Uzbekistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabokhat","family":"Sadikova","sequence":"additional","affiliation":[{"name":"Department of Chemistry Urgench State University  Urgench Uzbekistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-6675-6633","authenticated-orcid":false,"given":"Shaimaa","family":"Messa","sequence":"additional","affiliation":[{"name":"Young Researchers and Elite Club, Tehran Branch Islamic Azad University  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,7]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202515519"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.energyfuels.4c06234"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/acssuschemeng.5c05919"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202413182"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/adom.202402688"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2024.151177"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mssp.2025.109831"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stress.2024.100411"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202303845"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.4c06610"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202514590"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molliq.2024.126211"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.22034\/cpl.2025.545829.1005"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.ads7159"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sna.2024.115748"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202412276"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.4c01833"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/cey2.70018"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/nano14151266"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jlumin.2025.121281"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.2c00235"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surfin.2025.107164"},{"key":"e_1_2_10_24_1","first-page":"128","article-title":"Fe3O4@ MCM\u201041\u2010Cystine\u2010PdCl2 Nanocomposite: A Novel and Efficient Heterogeneous Catalyst for Synthesis of Coumarins","volume":"1","author":"Karezani M.","year":"2025","journal-title":"Chemical and Pharmaceutical Letters"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.snb.2022.132010"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.saa.2021.120659"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/ange.202204271"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.1c00689"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pmatsci.2024.101282"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-49172-6"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2023.165136"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.3390\/membranes12080753"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1QM00129A"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.5c08578"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/solr.202200023"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceramint.2023.12.328"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.1c12556"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1NR01990B"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2022.137583"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.3390\/inorganics13020055"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmst.2022.12.057"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apcatb.2023.122881"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.3390\/nano15090688"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.3390\/jmse11051001"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-031-78728-7_5"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.3390\/nano15040272"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1DT03624F"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.solener.2023.01.002"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ress.2024.110471"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abq3616"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2NJ02603A"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0NA00933D"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/cssc.202401875"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202105958"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-37943-6"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2022.137672"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2022.139904"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jpclett.5c01307"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jpclett.0c03317"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2025.164706"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202204763"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.optmat.2022.113070"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202500189"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.microc.2025.113263"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2021.06.088"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2022.139909"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.3390\/nano14131167"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.1c05907"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2TC00340F"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsanm.4c03489"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphotochem.2024.115803"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphotochem.2024.116172"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphotochem.2025.116282"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00604-024-06752-z"},{"key":"e_1_2_10_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphotochem.2023.115376"},{"key":"e_1_2_10_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.snb.2025.137489"},{"key":"e_1_2_10_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.microc.2024.110043"},{"key":"e_1_2_10_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2025.167280"},{"key":"e_1_2_10_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.microc.2022.107624"},{"key":"e_1_2_10_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2024.136655"},{"key":"e_1_2_10_81_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00604-024-06343-y"},{"issue":"49","key":"e_1_2_10_82_1","first-page":"56702","article-title":"Defect\u2010Passivated Photosensor Based on Cesium Lead Bromide (CsPbBr3) Perovskite Quantum Dots for Microbial Detection","volume":"15","author":"Park J. H.","year":"2023","journal-title":"ACS Applied Materials & Interfaces"},{"key":"e_1_2_10_83_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsanm.1c04493"},{"key":"e_1_2_10_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2025.344713"},{"key":"e_1_2_10_85_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11814-024-00303-1"}],"container-title":["Luminescence"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bio.70639","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/bio.70639","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bio.70639","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T16:54:18Z","timestamp":1792601658000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/bio.70639"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":84,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1002\/bio.70639"],"URL":"https:\/\/doi.org\/10.1002\/bio.70639","archive":["Portico"],"relation":{},"ISSN":["1522-7235","1522-7243"],"issn-type":[{"value":"1522-7235","type":"print"},{"value":"1522-7243","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"2025-12-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70639"}}