{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T17:38:17Z","timestamp":1792604297402,"version":"4.5.0"},"reference-count":37,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T00:00:00Z","timestamp":1791763200000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Luminescence"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The growing convergence between precision oncology and natural\u2010product\u2010based therapeutics has fostered innovative strategies that integrate molecularly targeted anticancer agents with biologically active phytochemicals to enhance therapeutic efficacy and overcome treatment resistance. Capmatinib, a selective MET inhibitor approved for MET\u2010driven non\u2010small cell lung cancer, and curcumin, a natural polyphenol possessing antioxidant, anti\u2010inflammatory, and anticancer activities, represent a promising therapeutic combination. This emerging paradigm highlights the need for sensitive, sustainable, and efficient analytical platforms capable of monitoring both compounds in pharmaceutical and biological matrices. Accordingly, two new spectrofluorimetric methods were created and validated, allowing for the quantification of capmatinib and the simultaneous assay of capmatinib\u2013curcumin combinations. The first method harnessed the unique microenvironmental properties of sodium dodecyl sulfate as a monomeric denaturant to markedly enhance the intrinsic fluorescence of capmatinib in an aqueous medium, providing a linear response over 5.0\u2013120.0\u2009ng\/mL with a detection limit of 1.42\u2009ng\/mL. The second method exploited synchronous spectrofluorimetry (\u0394\u03bb\u2009=\u2009160\u2009nm) to resolve overlapping fluorescence signals, enabling separation\u2010free quantification of capmatinib and curcumin across concentration ranges of 20.0\u2013700.0 and 10.0\u2013250.0\u2009ng\/mL, respectively. Both methods demonstrated excellent selectivity, accuracy, and precision according to ICH guidelines and were successfully applied to spiked human plasma samples.<\/jats:p>","DOI":"10.1002\/bio.70645","type":"journal-article","created":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T05:19:16Z","timestamp":1791868756000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Green Spectrofluorimetric Strategies for Capmatinib and Curcumin Determination"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1806-6465","authenticated-orcid":false,"given":"Mona E.","family":"El\u2010Sharkasy","sequence":"first","affiliation":[{"name":"Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy Mansoura University  Mansoura Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3953-7169","authenticated-orcid":false,"given":"Heba","family":"Elmansi","sequence":"additional","affiliation":[{"name":"Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy Mansoura University  Mansoura Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6242-2178","authenticated-orcid":false,"given":"Fathalla","family":"Belal","sequence":"additional","affiliation":[{"name":"Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy Mansoura University  Mansoura Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1489-4239","authenticated-orcid":false,"given":"Walaa Nabil","family":"Abd\u2010AlGhafar","sequence":"additional","affiliation":[{"name":"Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy Mansoura University  Mansoura Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,12]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21492"},{"key":"e_1_2_9_3_1","unstructured":"National Center for Biotechnology Information \u201cPubChem Compound Summary for CID 25145656 Capmatinib \u201d (2025) https:\/\/pubchem.ncbi.nlm.nih.gov\/compound\/Capmatinib."},{"key":"e_1_2_9_4_1","unstructured":"FDA U.S. Food and Drug Administration \u201cFDA Approves Capmatinib for Metastatic Non\u2010Small Cell Lung Cancer \u201dhttps:\/\/www.fda.gov\/drugs\/resources\u2010information\u2010approved\u2010drugs\/fda\u2010approves\u2010capmatinib\u2010metastatic\u2010non\u2010small\u2010cell\u2010lung\u2010cancer. 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