{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T12:42:07Z","timestamp":1762864927261,"version":"build-2065373602"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,5,27]],"date-time":"2005-05-27T00:00:00Z","timestamp":1117152000000},"content-version":"vor","delay-in-days":26,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Luminescence"],"published-print":{"date-parts":[[2005,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A chemiluminescent method for the determination of riboflavin is described. The method is based on the chemiluminescence (CL) generated during the oxidation of luminol by N\u2010bromosuccinimide (NBS) and N\u2010chlorosuccinimide (NCS) in alkaline medium. It was found that riboflavin could greatly enhance this CL intensity when present in the luminol solution. Based on this observation, a new flow\u2010injection CL method for the determination of riboflavin is proposed in this paper. The detection limits were 7.5 ng[sol ]mL and 3.5 ng[sol ]mL of riboflavin for the NBS\u2013 and NCS\u2013luminol CL systems, respectively. The relative CL intensity was linear, with riboflavin concentration in the range 19\u2013600 ng[sol ]mL and 600\u20132000 ng[sol ]mL for the NBS\u2013luminol CL system, and 12\u2013200 ng[sol ]mL and 200\u20132000 ng[sol ]mL for the NCS\u2013luminol CL system. The results obtained for the assay of pharmaceutical preparations compared well with those obtained by the official method and demonstrated good accuracy and precision. 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