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Curcumin also affects other signaling pathways including transforming growth factor\u2010\u03b2 and mitogen\u2010activated protein kinase pathway. Curcumin also modulates the phase II detoxification enzymes which are crucial in detoxification reactions and for protection against oxidative stress. In the present review, the biological mechanisms of the chemopreventive potential of curcumin in various skin diseases like psoriasis, vitiligo, and melanoma is discussed. The application of curcumin in skin regeneration and wound healing is also elucidated. We also explored the recent innovations and advances involved in the development of transdermal delivery systems to enhance the bioavailability of curcumin, particularly in the skin. Recent clinical trials pertaining to the use of curumin in skin diseases establishes its benefits and also the need for additional clinical trials in other diseases are discussed. \u00a9 2013 BioFactors, 39(1):141\u2013149, 2013<\/jats:p>","DOI":"10.1002\/biof.1078","type":"journal-article","created":{"date-parts":[[2013,1,12]],"date-time":"2013-01-12T04:44:23Z","timestamp":1357965863000},"page":"141-149","source":"Crossref","is-referenced-by-count":119,"title":["Skin regenerative potentials of curcumin"],"prefix":"10.1002","volume":"39","author":[{"given":"Rajesh L.","family":"Thangapazham","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shashwat","family":"Sharad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radha K.","family":"Maheshwari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,1,11]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1021\/mp700113r"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-46401-5_15"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules16064567"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1208\/aapsj080352"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2005.12.007"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1177\/030089168707300105"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.2174\/138945011794815356"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/593952"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-46401-5"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2007.12.035"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/3-540-37673-9_10"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0151-9638(06)70873-0"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0906-6705.2004.00205.x"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cr.7290259"},{"key":"e_1_2_8_16_2","first-page":"201","article-title":"Etanercept (Enbrel) for the treatment of moderate to severe plaque type psoriasis","volume":"61","author":"Pierard\u2010Franchimont C.","year":"2006","journal-title":"Rev. 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