{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T02:17:17Z","timestamp":1790389037125,"version":"4.1.0"},"reference-count":57,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,4,5]],"date-time":"2013-04-05T00:00:00Z","timestamp":1365120000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioFactors"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:p>The present investigation pertains to changes in substance P\u2010like immunoreactive (SP\u2010LI) nerve structures of the enteric nervous system (ENS) in the porcine descending colon, caused by chemically\u2010induced inflammation and nerve injury (axotomy). The distribution pattern of SP\u2010LI structures was studied using the double immunofluorescence technique in the myenteric (MP), outer submucous (OSP) and inner submucous (ISP) plexuses, as well as in the circular muscle and mucosal layers. Under physiological conditions, SP\u2010LI neurons have been shown to constitute 4.13 \u00b1 0.24%, 3.36 \u00b1 0.26%, and 7.92 \u00b1 0.16% in the MP, OSP, and ISP, respectively. Changes in SP\u2010immunoreactivity depended on the pathological factor studied. The numbers of the SP\u2010LI perikarya amounted to 7.89 \u00b1 0.34, 5.56 \u00b1 0.30, and 19.96 \u00b1 0.57 in chemically\u2010induced colitis, and 4.28 \u00b1 0.13%, 7.18 \u00b1 20%, and 11.62 \u00b1 0.48% after axotomy in MP, OSP, and ISP, respectively. The both studied processes generally resulted in an increase in the number of SP\u2010LI nerve fibers in the circular muscle and mucosal layers. The obtained results suggest that SP\u2010LI nerve structures of the ENS may participate in various pathological processes in the porcine descending colon and exact functions of SP probably depend on the type of the pathological factor. \u00a9 2013 BioFactors 39(5):542\u2013551, 2013<\/jats:p>","DOI":"10.1002\/biof.1097","type":"journal-article","created":{"date-parts":[[2013,4,5]],"date-time":"2013-04-05T08:58:35Z","timestamp":1365152315000},"page":"542-551","source":"Crossref","is-referenced-by-count":46,"title":["Substance P as a neuronal factor in the enteric nervous system of the porcine descending colon in physiological conditions and during selected pathogenic processes"],"prefix":"10.1002","volume":"39","author":[{"given":"Slawomir","family":"Gonkowski","sequence":"first","affiliation":[{"name":"Department of Clinical Physiology Faculty of Veterinary Medicine University of Warmia and Mazury Olsztyn Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,4,5]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-1838(00)00127-2"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1556\/AVet.57.2009.4.5"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.10-0081"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12031-011-9691-3"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2012.32"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-3150.2004.00475.x"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2007.04.005"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-0115(99)00080-4"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2006.02.025"},{"key":"e_1_2_5_11_1","first-page":"455","article-title":"The influence of experimental Bacteroides fragilis infection on substance P and somatostatin\u2010immunoreactive neural elements in the porcine ascending colon\u2014a preliminary report","volume":"62","author":"Gonkowski S.","year":"2003","journal-title":"Folia Morphol."},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1556\/AVet.58.2010.1.10"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexmp.2010.01.011"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-0115(00)00177-4"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-007-7148-1"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1474-8673.1993.tb00396.x"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2001.23251"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1471-4892(01)00100-X"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0185(20010101)262:1<58::AID-AR1011>3.0.CO;2-V"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.2001.00741.x"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2004.03.005"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcpa.2007.09.003"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rvsc.2009.03.011"},{"key":"e_1_2_5_24_1","first-page":"475","article-title":"Somatostatin, substance P and calcitonin gene\u2010related peptide\u2010positive intramural nerve structures of the human large intestine affected by carcinoma","volume":"30","author":"Godlewski J.","year":"2010","journal-title":"Folia Histochem. 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