{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T17:43:46Z","timestamp":1787679826411,"version":"build-2784847793"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,4,4]],"date-time":"2016-04-04T00:00:00Z","timestamp":1459728000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioFactors"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Aim:<\/jats:bold> to evaluate if a supplementation with n\u20103 PUFAs at high doses could give a regression of the condition of impaired glycemia. <jats:bold>Methods:<\/jats:bold> we enrolled 281 overweight\/obese patients with impaired fasting glucose (IFG) or impaired glucose tolerance (IGT); 138 subjects were randomized to n\u20103 PUFAs group, 1 g three times a day, and 143 to placebo for 18 months. We assessed at baseline, and after 9, and 18 months: circumferences, body mass index (BMI), fasting plasma glucose (FPG), fasting plasma insulin (FPI), HOMA\u2010index, lipid profile. At baseline and at the end of the study, all patients underwent an oral glucose tolerance test (OGTT). <jats:bold>Results:<\/jats:bold> we observed a decrease of glycemia and HOMA\u2010IR with n\u20103 PUFAs, compared to baseline, and to placebo. Fasting plasma insulin decreased with n\u20103 PUFAs and increased with placebo. HDL\u2010cholesterol increased after 18 months of n\u20103 PUFAs, while triglycerides decreased compared to baseline and to placebo. After OGTT performed at the end of the study, more patients returned to a condition of euglycemia with n\u20103 PUFAs compared to placebo. <jats:bold>Conclusions:<\/jats:bold> n\u20103 PUFAs were effective in reducing glycemia in patients affected by IFG or IGT and seem to be helpful to slow the development of type 2 diabetes mellitus. \u00a9 2016 BioFactors, 42(3):316\u2013322, 2016<\/jats:p>","DOI":"10.1002\/biof.1277","type":"journal-article","created":{"date-parts":[[2023,10,7]],"date-time":"2023-10-07T01:57:18Z","timestamp":1696643838000},"page":"316-322","source":"Crossref","is-referenced-by-count":52,"title":["Effects of n\u20103 pufas on fasting plasma glucose and insulin resistance in patients with impaired fasting glucose or impaired glucose tolerance"],"prefix":"10.1002","volume":"42","author":[{"given":"Giuseppe","family":"Derosa","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and Therapeutics University of Pavia, Fondazione IRCCS Policlinico S. Matteo PAVIA Italy"},{"name":"Center for the Study of Endocrine\u2010Metabolic Pathophysiology and Clinical Research, University of Pavia PAVIA Italy"},{"name":"Center for Prevention, Surveillance, Diagnosis and Treatment of Rare Diseases, Fondazione IRCCS Policlinico S. Matteo Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arrigo F.G.","family":"Cicero","sequence":"additional","affiliation":[{"name":"Center for Prevention, Surveillance, Diagnosis and Treatment of Rare Diseases, Fondazione IRCCS Policlinico S. Matteo Pavia Italy"},{"name":"Internal Medicine, Aging and Kidney Disease Department, University of Bologna BOLOGNA Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"D'Angelo","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Therapeutics University of Pavia, Fondazione IRCCS Policlinico S. 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