{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T16:14:19Z","timestamp":1773850459284,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2010,11,11]],"date-time":"2010-11-11T00:00:00Z","timestamp":1289433600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioFactors"],"published-print":{"date-parts":[[2011,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Astaxanthin is a red carotenoid pigment and is widely found in living organisms. Astaxanthin has a potent antioxidative ability and has been reported as having various biological effects on the central nerve system, such as a protective effect against ischemia\/reperfusion injury and improvement in cognitive function. In this study, to investigate the effects of astaxanthin on anxiety and depression, we performed some behavioral trials including the elevated plus maze test, hole\u2010board test, forced swim test, and tail suspension test. Astaxanthin (100 and 300 mg\/kg\/day for 10 days, p.o.) significantly increased the time spent in open arms in the elevated plus maze test and increased the head\u2010dipping count and duration in the hole\u2010board test. On the other hand, astaxanthin (10, 100, 300, and 500 mg\/kg\/day for 10 days, p.o.) did not change the immobility time in the forced swim test or the tail suspension test. In conclusion, in mice, astaxanthin exerted anxiolytic\u2010like effects, but not antidepressant\u2010like effects.<\/jats:p>","DOI":"10.1002\/biof.130","type":"journal-article","created":{"date-parts":[[2010,11,11]],"date-time":"2010-11-11T13:20:03Z","timestamp":1289481603000},"page":"25-30","source":"Crossref","is-referenced-by-count":15,"title":["The antianxiety\u2010like effect of astaxanthin extracted from <i>Paracoccus carotinifaciens<\/i>"],"prefix":"10.1002","volume":"37","author":[{"given":"Yasushi","family":"Nishioka","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Oyagi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiro","family":"Tsuruma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masamitsu","family":"Shimazawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Ishibashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideaki","family":"Hara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,11,11]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1351\/pac199163010141"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0005-2736(01)00326-1"},{"key":"e_1_2_5_4_2","unstructured":"Tso M. O. M.andLam T. T.(1996) Method of retarding and ameliorating central nervous system and eye damage. 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