{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T22:47:26Z","timestamp":1789426046496,"version":"build-2803163510"},"reference-count":79,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,6,14]],"date-time":"2016-06-14T00:00:00Z","timestamp":1465862400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioFactors"],"published-print":{"date-parts":[[2016,11,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Oxidative stress, ER stress, inflammation, and apoptosis results in the pathogenesis of cisplatin\u2010induced cardiotoxicity. The present study was designed to investigate the signaling mechanisms involved in the ameliorating effect of taurine, a conditionally essential amino acid, against cisplatin\u2010mediated cardiac ER stress dependent apoptotic death and inflammation. Mice were simultaneously treated with taurine (150 mg\u00a0kg\n                    <jats:sup>\u22121<\/jats:sup>\n                    body wt, i.p.) and cisplatin (10 mg\u00a0kg\n                    <jats:sup>\u22121<\/jats:sup>\n                    body wt, i.p.) for a week. Cisplatin exposure significantly altered serum creatine kinase and troponin T levels. In addition, histological studies revealed disintegration in the normal radiation pattern of cardiac muscle fibers. However, taurine administration could abate such adverse effects of cisplatin. Taurine administration significantly mitigated the reactive oxygen species production, alleviated the overexpression of nuclear factor\u2010\u03baB (NF\u2010\u03baB), and inhibited the elevation of proinflammatoy cytokines, adhesion molecules, and chemokines. Cisplatin exposure resulted in the unfolded protein response (UPR)\u2010regulated CCAAT\/enhancer binding protein (CHOP) up\u2010regulation, induction of GRP78: a marker of ER stress and eIF2\u03b1 signaling. Increase in calpain\u20101 expression level, activation of caspase\u201012 and caspase\u20103, cleavage of the PARP protein as well as the inhibition of antiapoptotic protein Bcl\u20102 were reflected on cisplatin\u2010triggered apoptosis. Taurine could, however, combat against such cisplatin induced cardiac\u2010abnormalities. The above mentioned findings suggest that taurine plays a beneficial role in providing protection against cisplatin\u2010induced cardiac damage by modulating inflammatory responses and ER stress. \u00a9 2016 BioFactors, 42(6):647\u2013664, 2016\n                  <\/jats:p>","DOI":"10.1002\/biof.1301","type":"journal-article","created":{"date-parts":[[2016,12,21]],"date-time":"2016-12-21T02:15:36Z","timestamp":1482286536000},"page":"647-664","source":"Crossref","is-referenced-by-count":124,"title":["Taurine protects cisplatin induced cardiotoxicity by modulating inflammatory and endoplasmic reticulum stress responses"],"prefix":"10.1002","volume":"42","author":[{"given":"Sayantani","family":"Chowdhury","sequence":"first","affiliation":[{"name":"Division of Molecular Medicine Bose Institute P\u20101\/12, CIT Scheme VII M Kolkata India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krishnendu","family":"Sinha","sequence":"additional","affiliation":[{"name":"Division of Molecular Medicine Bose Institute P\u20101\/12, CIT Scheme VII M Kolkata India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharmistha","family":"Banerjee","sequence":"additional","affiliation":[{"name":"Division of Molecular Medicine Bose Institute P\u20101\/12, CIT Scheme VII M Kolkata India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parames C.","family":"Sil","sequence":"additional","affiliation":[{"name":"Division of Molecular Medicine Bose Institute P\u20101\/12, CIT Scheme VII M Kolkata India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,6,14]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1992.10.4.574"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfp242"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-06-1037"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-007-9508-3"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2010.09.085"},{"key":"e_1_2_5_7_1","first-page":"147","article-title":"Ameliorating effect of dl\u2010alpha\u2010lipoic acid against cisplatin\u2010induced nephrotoxicity and cardiotoxicity in experimental animals","volume":"6","author":"Hussein A.","year":"2012","journal-title":"Drug Discov. 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