{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T11:07:40Z","timestamp":1749640060625},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,9,24]],"date-time":"2016-09-24T00:00:00Z","timestamp":1474675200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"KAKENHI GRANT","award":["23602012","26460239"],"award-info":[{"award-number":["23602012","26460239"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioFactors"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cardiac fibrosis is the major hallmark of adverse cardiac remodeling in chronic heart failure (CHF) and its therapeutic targeting might help against cardiac dysfunction during chronic conditions. Diuretic agents are potentially useful in these cases, but their effects on the cardiac fibrosis pathogenesis are yet to be identified. This study was designed to identify and compare the effects of diuretic drugs torasemide and furosemide on cardiac fibrosis in a rat model of dilated cardiomyopathy induced by porcine cardiac myosin mediated experimental autoimmune myocarditis. Gap junction proteins, connexin\u201043 and N\u2010cadherin, expressions were downregulated in the hearts of CHF rats, while torasemide treatment has upregulated their expression. Western blotting and immunohistochemical analysis for various cardiac fibrosis related proteins as well as histopathological studies have shown that both drugs have potential anti\u2010fibrotic effects. Among them, torasemide has superior efficacy in offering protection against adverse cardiac remodeling in the selected rat model of dilated cardiomyopathy. In conclusion, torasemide treatment has potential anti\u2010fibrotic effect in the hearts of CHF rats, possibly via improving the gap junction proteins expression and thereby improving the cell\u2013cell interaction in the heart. \u00a9 2016 BioFactors, 43(2):187\u2013194, 2017<\/jats:p>","DOI":"10.1002\/biof.1332","type":"journal-article","created":{"date-parts":[[2016,9,24]],"date-time":"2016-09-24T06:53:10Z","timestamp":1474699990000},"page":"187-194","source":"Crossref","is-referenced-by-count":6,"title":["Comparative effects of torasemide and furosemide on gap junction proteins and cardiac fibrosis in a rat model of dilated cardiomyopathy"],"prefix":"10.1002","volume":"43","author":[{"given":"Kenichi","family":"Watanabe","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences Niigata University of Pharmacy and Applied Life Sciences Niigata City Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Remya","family":"Sreedhar","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences Niigata University of Pharmacy and Applied Life Sciences Niigata City Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajarajan A.","family":"Thandavarayan","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Sciences Houston Methodist Research Institute Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vengadeshprabhu","family":"Karuppagounder","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences Niigata University of Pharmacy and Applied Life Sciences Niigata City Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vijayasree V.","family":"Giridharan","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences University of Texas Health Science Center at Houston Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shanish","family":"Antony","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Government Medical College Kottayam Kerala India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meilei","family":"Harima","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences Niigata University of Pharmacy and Applied Life Sciences Niigata City Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiko","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Cardiology Yamanashi Prefectural Central Hospital Kofu Yamanashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Niigata University Graduate School of Medical and Dental Sciences Niigata City Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences Niigata University of Pharmacy and Applied Life Sciences Niigata City Japan"},{"name":"Department of Hematology, Endocrinology and Metabolism Niigata University of Graduate School of Medicine and Dental Sciences Niigata City Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirohito","family":"Sone","sequence":"additional","affiliation":[{"name":"Department of Hematology, Endocrinology and Metabolism Niigata University of Graduate School of Medicine and Dental Sciences Niigata City Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Somasundaram","family":"Arumugam","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences Niigata University of Pharmacy and Applied Life Sciences Niigata City Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,9,24]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00515.2010"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2003.12.010"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2010.01.017"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000181132.11393.18"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2007.11.013"},{"key":"e_1_2_8_7_1","doi-asserted-by":"crossref","first-page":"S494","DOI":"10.1161\/circ.118.suppl_18.S_494","article-title":"Abstract 3860: arrhythmia vulnerability of aged haploinsufficient Cx43 mice is determined by heterogeneous downregulation of Cx43 combined with increased fibrosis","volume":"118","author":"Jansen J. 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