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However, early alterations on renal function, mitochondrial dynamics, and oxidative stress have not been explored yet. Curcumin is an antioxidant that has shown nephroprotection in 5\/6NX\u2010induced renal damage. The aim of this study was to explore the effect of curcumin on early mitochondrial alterations induced by 5\/6NX in rats. In isolated mitochondria, 5\/6NX\u2010induced hydrogen peroxide production was associated with decreased activity of complexes I and V, decreased activity of antioxidant enzymes, alterations in oxygen consumption and increased MDA\u2010protein adducts. In addition, it was found that 5\/6NX shifted mitochondrial dynamics to fusion, which was evidenced by increased optic atrophy 1 and mitofusin 1 (Mfn1) and decreased fission 1 and dynamin\u2010related protein 1 expressions. These data were confirmed by morphological analysis and immunoelectron microscopy of Mfn\u20101. All the above\u2010described mechanisms were prevented by curcumin. Also, it was found that curcumin prevented renal dysfunction by improving renal blood flow and the total antioxidant capacity induced by 5\/6NX. Moreover, in glomeruli and proximal tubules 5\/6NX\u2010induced superoxide anion production by uncoupled nitric oxide synthase (NOS) and nicotinamide adenine dinucleotide phosphate oxidase (NOX) dependent way, this latter was associated with increased phosphorylation of serine 304 of p47phox subunit of NOX. In conclusion, this study shows that curcumin pretreatment decreases early 5\/6NX\u2010induced altered mitochondrial dynamics, bioenergetics, and oxidative stress, which may be associated with the preservation of renal function. \u00a9 2016 BioFactors, 43(2):293\u2013310, 2017<\/jats:p>","DOI":"10.1002\/biof.1338","type":"journal-article","created":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T14:43:54Z","timestamp":1478011434000},"page":"293-310","source":"Crossref","is-referenced-by-count":83,"title":["Curcumin prevents mitochondrial dynamics disturbances in early 5\/6 nephrectomy: Relation to oxidative stress and mitochondrial bioenergetics"],"prefix":"10.1002","volume":"43","author":[{"given":"Omar Emiliano","family":"Aparicio\u2010Trejo","sequence":"first","affiliation":[{"name":"Department of Biology, Faculty of Chemistry National Autonomous University of Mexico (UNAM) Mexico City 04510 Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edilia","family":"Tapia","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Laboratory of Renal Pathophysiology National Institute of Cardiology \u201cIgnacio Ch\u00e1vez\u201d Mexico City 14080 Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Molina\u2010Jij\u00f3n","sequence":"additional","affiliation":[{"name":"Departamento de Biociencias e Ingenier\u00eda Centro Interdisciplinario de Investigaciones y Estudios sobre Medio Ambiente y Desarrollo del Instituto Polit\u00e9cnico Nacional (CIIEMAD\u2010IPN) Ciudad de M\u00e9xico 07340 M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar Noel","family":"Medina\u2010Campos","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Chemistry National Autonomous University of Mexico (UNAM) Mexico City 04510 Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norma Ang\u00e9lica","family":"Mac\u00edas\u2010Ruvalcaba","sequence":"additional","affiliation":[{"name":"Department of Physical Chemistry, Faculty of Chemistry National Autonomous University of Mexico (UNAM) Mexico City 04510 Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Carlos","family":"Le\u00f3n\u2010Contreras","sequence":"additional","affiliation":[{"name":"Experimental Pathology Section National Institute of Medical Sciences and Nutrition \u201cSalvador Zubir\u00e1n\u201d Mexico City 14000 Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rogelio","family":"Hern\u00e1ndez\u2010Pando","sequence":"additional","affiliation":[{"name":"Experimental Pathology Section National Institute of Medical Sciences and Nutrition \u201cSalvador Zubir\u00e1n\u201d Mexico City 14000 Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando E.","family":"Garc\u00eda\u2010Arroyo","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Laboratory of Renal Pathophysiology National Institute of Cardiology \u201cIgnacio Ch\u00e1vez\u201d Mexico City 14080 Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Crist\u00f3bal","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Laboratory of Renal Pathophysiology National Institute of Cardiology \u201cIgnacio Ch\u00e1vez\u201d Mexico City 14080 Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura Gabriela","family":"S\u00e1nchez\u2010Lozada","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Laboratory of Renal Pathophysiology National Institute of Cardiology \u201cIgnacio Ch\u00e1vez\u201d Mexico City 14080 Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"Pedraza\u2010Chaverri","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Chemistry National Autonomous University of Mexico (UNAM) Mexico City 04510 Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,11]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)60687-X"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)17789-7"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2005.09702.x"},{"key":"e_1_2_7_5_1","first-page":"405","article-title":"Peritoneal dialysis in Latin America","volume":"27","author":"Paniagua R.","year":"2007","journal-title":"Peritoneal Dial. 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