{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T02:42:36Z","timestamp":1783392156298,"version":"3.54.6"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,1,31]],"date-time":"2017-01-31T00:00:00Z","timestamp":1485820800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioFactors"],"published-print":{"date-parts":[[2017,5,6]]},"abstract":"<jats:p>Ze339, an herbal extract from <jats:italic>Petasites hybridus<\/jats:italic> leaves is effective in treatment of allergic rhinitis by inhibition of a local production of IL\u20108 and eicosanoid LTB<jats:sub>4<\/jats:sub> in allergen\u2010challenged patients. However, the mechanism of action and anti\u2010inflammatory potential in virally induced exacerbation of the upper airways is unknown. This study investigates the anti\u2010inflammatory mechanisms of Ze339 on primary human nasal epithelial cells (HNECs) upon viral, bacterial and pro\u2010inflammatory triggers. To investigate the influence of viral and bacterial infections on the airways, HNECs were stimulated with viral mimics, bacterial toll\u2010like\u2010receptor (TLR)\u2010ligands or cytokines, in presence or absence of Ze339. The study uncovers Ze339 modulated changes in pro\u2010inflammatory mediators and decreased neutrophil chemotaxis as well as a reduction of the nuclear translocation and phosphorylation of STAT molecules. Taken together, this study suggests that phyto drug Ze339 specifically targets STAT\u2010signalling pathways in HNECs and has high potential as a broad anti\u2010inflammatory drug that exceeds current indication. \u00a9 2016 BioFactors, 43(3):388\u2013399, 2017<\/jats:p>","DOI":"10.1002\/biof.1349","type":"journal-article","created":{"date-parts":[[2017,1,31]],"date-time":"2017-01-31T07:34:27Z","timestamp":1485848067000},"page":"388-399","source":"Crossref","is-referenced-by-count":20,"title":["Anti\u2010inflammatory effects of the petasin phyto drug <scp>Z<\/scp>e339 are mediated by inhibition of the STAT pathway"],"prefix":"10.1002","volume":"43","author":[{"given":"Sabrina A.","family":"Steiert","sequence":"first","affiliation":[{"name":"Center of Allergy &amp; Environment (ZAUM), Technical University of Munich and Helmholtz Center Munich, German Research Center for Environmental Health, Germany, Member of the German Center for Lung Research (DZL) Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich M.","family":"Zissler","sequence":"additional","affiliation":[{"name":"Center of Allergy &amp; 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