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The aim of the study is to characterize the molecular effects determined by Se\u2010supplementation in thyroid follicular cells, using as model the well\u2010differentiated rat thyroid follicular cell line FRTL5. Experiments have been performed to evaluate the effects of Se on cell growth, mortality and proliferation and on modulation of pro\u2010 and antiapoptotic pathways. The results indicate that Se\u2010supplementation improves FRTL5 growth rate. Furthermore, Se reduces the proportion of cell death and modulates both proapoptotic (<jats:italic>p53 and Bim<\/jats:italic>) and antiapoptotic (<jats:italic>NF\u2010kB<\/jats:italic> and <jats:italic>Bcl2)<\/jats:italic> mRNA levels. In addition, incubation with high doses of Na\u2013Se might prevent the ER\u2010stress apoptosis induced by tunicamycin, as assessed by membrane integrity maintenance, reduction in caspase 3\/7 activities, and reduction in Casp\u20103 and PARP cleavage. Taken together, these results provide molecular evidences indicating the role of Se supplementation on cell death and apoptosis modulation in thyroid follicular cells. These observations may be useful to understand the effects of this micronutrient on the physiopathology of the thyroid gland. \u00a9 2016 BioFactors, 43(3):415\u2013423, 2017<\/jats:p>","DOI":"10.1002\/biof.1351","type":"journal-article","created":{"date-parts":[[2017,3,2]],"date-time":"2017-03-02T06:42:54Z","timestamp":1488436974000},"page":"415-423","source":"Crossref","is-referenced-by-count":31,"title":["Selenium supplementation modulates apoptotic processes in thyroid follicular cells"],"prefix":"10.1002","volume":"43","author":[{"given":"Immacolata C.","family":"Nettore","sequence":"first","affiliation":[{"name":"Dipartimento di Medicina Clinica e Chirurgia Universit\u00e0 degli Studi di Napoli \u201cFederico II\u201d Napoli 80131 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"De Nisco","sequence":"additional","affiliation":[{"name":"Dipartimento di Medicina Clinica e Chirurgia Universit\u00e0 degli Studi di Napoli \u201cFederico II\u201d Napoli 80131 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvio","family":"Desiderio","sequence":"additional","affiliation":[{"name":"Dipartimento di Medicina Clinica e Chirurgia Universit\u00e0 degli Studi di Napoli \u201cFederico II\u201d Napoli 80131 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmela","family":"Passaro","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Mediche Traslazionali Universit\u00e0 degli Studi di Napoli \u201cFederico II\u201d Napoli 80131 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Maione","sequence":"additional","affiliation":[{"name":"Dipartimento di Medicina Clinica e Chirurgia Universit\u00e0 degli Studi di Napoli \u201cFederico II\u201d Napoli 80131 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariarosaria","family":"Negri","sequence":"additional","affiliation":[{"name":"I.O.S. and COLEMAN S.r.l Naples 80100 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Albano","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Mediche Traslazionali Universit\u00e0 degli Studi di Napoli \u201cFederico II\u201d Napoli 80131 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosario","family":"Pivonello","sequence":"additional","affiliation":[{"name":"Dipartimento di Medicina Clinica e Chirurgia Universit\u00e0 degli Studi di Napoli \u201cFederico II\u201d Napoli 80131 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Pivonello","sequence":"additional","affiliation":[{"name":"Dipartimento di Medicina Clinica e Chirurgia Universit\u00e0 degli Studi di Napoli \u201cFederico II\u201d Napoli 80131 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Portella","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Mediche Traslazionali Universit\u00e0 degli Studi di Napoli \u201cFederico II\u201d Napoli 80131 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Ungaro","sequence":"additional","affiliation":[{"name":"Istituto di Endocrinologia ed Oncologia Sperimentale del CNR (IEOS\u2010CNR) \u201cG. 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