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Celecoxib (COX\u20102 selective inhibitor) (5 mg\/kg b.wt) was used as a reference drug. CA remarkably suppressed the paw edema, body weight loss and inflammatory cytokine and chemokine levels (TNF\u2010\u03b1, IL\u20101\u03b2, IL\u20106, and MCP\u20101) in serum and ankle joint of arthritic rats. Consistently, CA reduced the expression of osteoclastogenic factors (RANKL and TRAP), pro\u2010inflammatory cytokines (TNF\u2010\u03b1, IL\u20101\u03b2, IL\u20106, and IL\u201017), and inflammatory enzymes (iNOS and COX\u20102) in arthritic rats. However, OPG expression was found elevated. Besides, the abundance of transcription factors (NF\u2010\u03baB\u2010p65, and p\u2010NF\u2010\u03baB\u2010p65, NFATc\u20101, and c\u2010Fos) and MAP kinases (JNK, p\u2010JNK, and ERK1\/2) expression was alleviated in CA administered arthritic rats. In addition, CA truncated osteoclastogenesis by regulating the RANKL\/OPG imbalance in arthritic rats and suppressing the RANKL\u2010induced NFATc\u20101 and c\u2010Fos expression\n                    <jats:italic>in vitro<\/jats:italic>\n                    . Radiological (CT and DEXA scan) and histological assessments authenticated that CA inhibited TRAP, bone destruction and cartilage degradation in association with enhanced bone mineral density. Taken together, our findings suggest that CA demonstrated promising anti\u2010arthritic effect and could prove useful as an alternative drug in RA therapeutics. \u00a9 2017 BioFactors, 43(5):698\u2013717, 2017\n                  <\/jats:p>","DOI":"10.1002\/biof.1377","type":"journal-article","created":{"date-parts":[[2017,7,25]],"date-time":"2017-07-25T09:18:44Z","timestamp":1500974324000},"page":"698-717","source":"Crossref","is-referenced-by-count":65,"title":["<i>p<\/i>\n                    \u2010Coumaric acid, a dietary polyphenol ameliorates inflammation and curtails cartilage and bone erosion in the rheumatoid arthritis rat model"],"prefix":"10.1002","volume":"43","author":[{"given":"Manoj Kumar","family":"Neog","sequence":"first","affiliation":[{"name":"Immunopathology Lab, School of Bio Sciences and Technology VIT University Vellore Tamil Nadu 632 014 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Joshua Pragasam","sequence":"additional","affiliation":[{"name":"Immunopathology Lab, School of Bio Sciences and Technology VIT University Vellore Tamil Nadu 632 014 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moorthy","family":"Krishnan","sequence":"additional","affiliation":[{"name":"Division of Biomedical Sciences University of California Riverside Riverside CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4980-5355","authenticated-orcid":false,"given":"Mahaboobkhan","family":"Rasool","sequence":"additional","affiliation":[{"name":"Immunopathology Lab, School of Bio Sciences and Technology VIT University Vellore Tamil Nadu 632 014 India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,7,25]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1004965"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keg209"},{"key":"e_1_2_8_4_1","doi-asserted-by":"crossref","first-page":"2603","DOI":"10.4049\/jimmunol.147.8.2603","article-title":"Cytokine\u2010induced IL\u20101 beta gene expression in the human polymorphonuclear leukocyte: transcriptional and post\u2010transcriptional regulation by tumor necrosis factor and IL\u20101","volume":"147","author":"Marucha P. 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