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Magnesium Isoglycyrrhizinate (MgIG) has been accepted to be a neuroprotective effect, hepatoprotective and anti\u2010inflammatory molecule. In our vitro researches, MgIG was considered to activate hepatic stellate cells (HSCs) apoptosis by promoting endoplasmic reticulum stress (ERS) detrimental response to a certain extent. Consequently, MgIG showed its potential therapeutic capacity in fibrogenesis and counteracted the pathogenetic aspects, which were involved in integrating current treatments correcting liver fibrosis. In addition, we further verificated the behavior and pathogenic mechanisms in the CCl<jats:sub>4<\/jats:sub>\u2010induced liver fibrosis in male mice. What surprised us was that with the treatment of MgIG caused the activation of ERS and resisted the activated HSCs in the protective effects on liver damage. We found MgIG significantly promoted the apoptosis of activated HSCs and protected the CCl<jats:sub>4<\/jats:sub>\u2010induced liver fibrosis. Main molecules came down to the unfolded protein response signaling pathway. Furthermore, MgIG inhibited the levels of the downstream inflammatory cytokines, which were triggered by CCl<jats:sub>4<\/jats:sub>\u2010induced liver fibrosis. Here, we reported that MgIG improved behavioral impairments induced by intraperitoneal injection of CCl<jats:sub>4<\/jats:sub> and decreased the expression of proinflammatory factor, which indicated the preserving effects on liver fibrosis. \u00a9 2017 BioFactors, 43(6):836\u2013846, 2017<\/jats:p>","DOI":"10.1002\/biof.1390","type":"journal-article","created":{"date-parts":[[2017,10,19]],"date-time":"2017-10-19T13:12:39Z","timestamp":1508418759000},"page":"836-846","source":"Crossref","is-referenced-by-count":33,"title":["Magnesium isoglycyrrhizinate promotes the activated hepatic stellate cells apoptosis via endoplasmic reticulum stress and ameliorates fibrogenesis <i>in vitro<\/i> and <i>in vivo<\/i>"],"prefix":"10.1002","volume":"43","author":[{"given":"Mianli","family":"Bian","sequence":"first","affiliation":[{"name":"Department of Pharmacology, School of Pharmacy Nanjing University of Chinese Medicine Nanjing Jiangsu China"},{"name":"Jiangsu Key Laboratory for Pharmacology and 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