{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T12:13:45Z","timestamp":1782216825462,"version":"3.54.5"},"reference-count":54,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,2,5]],"date-time":"2018-02-05T00:00:00Z","timestamp":1517788800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004281","name":"National Science Centre of Poland","doi-asserted-by":"publisher","award":["2012\/07\/D\/ST4\/02177"],"award-info":[{"award-number":["2012\/07\/D\/ST4\/02177"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005911","name":"IRH","doi-asserted-by":"publisher","award":["INCT (020\u2010605)"],"award-info":[{"award-number":["INCT (020\u2010605)"]}],"id":[{"id":"10.13039\/100005911","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004625","name":"UITM","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004625","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioFactors"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In view of the interrelations between NO, Fe, and LDL in the cardiovascular system it appears interesting to find out, if the lipoprotein particles undergo the process of iron\u2010nitrosylation, commonly observed for other proteins and what is the biological fate of iron\u2010nitrosylated LDL particles. Iron\u2010nitrosylated LDL preparation containing Fe(NO)<jats:sub>2<\/jats:sub> motif (DNICLDL) was obtained and characterized for the first time. In order to test its interactions with potential target cells, DNICLDL was administered to the hepatoma HepG2 cells. The effects were referred to those induced by native LDL (nLDL) and oxidized LDL (oxLDL) particles. DNICLDL administration considerably increased total iron content in the studied cell line, but did not influence the level of calcein\u2010chelatable ions. DNICLDL was found to be low toxic to cells. The study suggests that DNICLDL might be a potential transducer of iron. \u00a9 2017 BioFactors, 44(2):192\u2013201, 2018<\/jats:p>","DOI":"10.1002\/biof.1412","type":"journal-article","created":{"date-parts":[[2018,2,5]],"date-time":"2018-02-05T05:46:36Z","timestamp":1517809596000},"page":"192-201","source":"Crossref","is-referenced-by-count":7,"title":["LDL dinitrosyl iron complex: A new transferrin\u2010independent route for iron delivery in hepatocytes"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1960-1071","authenticated-orcid":false,"given":"Hanna","family":"Lewandowska","sequence":"first","affiliation":[{"name":"Institute of Nuclear Chemistry and Technology 16 Dorodna Str, Warsaw, 03\u2010195 Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylwia","family":"M\u0119czy\u0144ska\u2010Wielgosz","sequence":"additional","affiliation":[{"name":"Institute of Nuclear Chemistry and Technology 16 Dorodna Str, Warsaw, 03\u2010195 Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarzyna","family":"Sikorska","sequence":"additional","affiliation":[{"name":"Institute of Nuclear Chemistry and Technology 16 Dorodna Str, Warsaw, 03\u2010195 Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaros\u0142aw","family":"Sad\u0142o","sequence":"additional","affiliation":[{"name":"Institute of Nuclear Chemistry and Technology 16 Dorodna Str, Warsaw, 03\u2010195 Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakub","family":"Dudek","sequence":"additional","affiliation":[{"name":"Institute of Nuclear Chemistry and Technology 16 Dorodna Str, Warsaw, 03\u2010195 Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcin","family":"Kruszewski","sequence":"additional","affiliation":[{"name":"Institute of Nuclear Chemistry and Technology 16 Dorodna Str, Warsaw, 03\u2010195 Poland"},{"name":"Faculty of Medicine University of Information Technology and Management in Rzesz\u00f3w ul. Sucharskiego 2, Rzesz\u00f3w, 35\u2010225 Poland"},{"name":"Department of Molecular Biology and Translational Research Institute of Rural Health Jaczewskiego 2, Lublin, 20\u2010090 Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,2,5]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehl012"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMe0910313"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehm328"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2012.746299"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2002.00314.x"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12878-016-0046-8"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0117383"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2014.10.007"},{"key":"e_1_2_9_10_1","first-page":"579","article-title":"Free radicals, oxidative stress, oxidized low density lipoprotein (LDL), and the heart: antioxidants and other strategies to limit cardiovascular damage","volume":"59","author":"Sinatra S. T.","year":"1995","journal-title":"Conn. Med."},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.3945\/jn.109.110353"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9150(94)90192-9"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0033-0620(05)80001-5"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/cphy.c120016"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2275(20)35728-X"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.2174\/1566524033479582"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.87.3.1223"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.4240\/wjgs.v6.i7.122"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v23.i14.2505"},{"key":"e_1_2_9_20_1","volume-title":"Principles of Anatomy and Physiology","author":"Tortora G. J.","year":"2008"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1039\/c0dt01244k"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/430_2013_102"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01024895"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.3513311"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI111044"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)35718-6"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsps.2013.12.015"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-59745-198-7_2"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI103182"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2014.04.020"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1006\/abio.1997.2126"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1021\/ci049863s"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2795(68)90204-3"},{"key":"e_1_2_9_34_1","unstructured":"APOB \u2010 Apolipoprotein B\u2010100 precursor \u2010 Homo sapiens (Human) \u2010 APOB gene & protein n.d.http:\/\/www.uniprot.org\/uniprot\/P04114#section_seq(accessed March 23 2016)."},{"key":"e_1_2_9_35_1","unstructured":"ExPASy \u2010 ProtScale n.d.http:\/\/web.expasy.org\/protscale\/(accessed March 23 2016)."},{"key":"e_1_2_9_36_1","doi-asserted-by":"crossref","first-page":"2622","DOI":"10.1016\/S0022-2275(20)41098-3","article-title":"Purification of the apolipoprotein B\u201067\u2010containing low density lipoprotein particle and its affinity for the low density lipoprotein receptor","volume":"36","author":"Welty F. K.","year":"1995","journal-title":"J. Lipid Res."},{"key":"e_1_2_9_37_1","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1016\/S0022-2275(20)42751-8","article-title":"A cross\u2010species comparison of the apolipoprotein B domain that binds to the LDL receptor","volume":"31","author":"Law A.","year":"1990","journal-title":"J. Lipid Res."},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1003557"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-044452236-8\/50007-1"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a013219"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V86.6.2168.bloodjournal8662168"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2013.07.002"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0710416106"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-2952(01)00869-3"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/chin.201013222"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.2478\/v10136-012-0025-8"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2275(20)41494-4"},{"key":"e_1_2_9_48_1","doi-asserted-by":"crossref","first-page":"2223","DOI":"10.1016\/S0022-2275(20)39928-4","article-title":"Cryo\u2010electron microscopy reveals human low density lipoprotein substructure","volume":"35","author":"Antwerpen R.","year":"1994","journal-title":"J. Lipid Res."},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0018841"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10439-005-8980-9"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.51.1046"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.niox.2006.09.005"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005344-198406002-00008"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/34402"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M005387200"}],"container-title":["BioFactors"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbiof.1412","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iubmb.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/biof.1412","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T14:14:40Z","timestamp":1695564880000},"score":1,"resource":{"primary":{"URL":"https:\/\/iubmb.onlinelibrary.wiley.com\/doi\/10.1002\/biof.1412"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,5]]},"references-count":54,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,3]]}},"alternative-id":["10.1002\/biof.1412"],"URL":"https:\/\/doi.org\/10.1002\/biof.1412","archive":["Portico"],"relation":{},"ISSN":["0951-6433","1872-8081"],"issn-type":[{"value":"0951-6433","type":"print"},{"value":"1872-8081","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2,5]]}}}