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Numerous studies established that superoxide anion radical production by heart mitochondria is only slightly suppressed under conditions of deep hypoxia, but is completely blocked under anoxia. It was found also that dinitrosyl iron complexes (DNIC) compare favourably with other physiologically active derivatives of nitric oxide (NO). DNIC with glutathione effectively scavenge superoxide radicals generated by mitochondria at different partial pressures of oxygen. Under conditions of simulated hypoxia, the synthesis of thiol\u2010containing DNIC takes place in mitochondria and is concomitant with a significant decrease in the concentration of NO metabolites at the reoxygenation step. Free NO required for DNIC synthesis is generated in the reaction of S\u2010nitrosothiols with superoxide or during single\u2010electron oxidation of the nitroxyl radical (HNO) by coenzyme Q. Plausible mechanisms of antiradical effects of DNIC and their protective role in oxidative stress induced by hypoxia\/reoxygenation of myocardial tissues are considered. \u00a9 2018 BioFactors, 44(3):237\u2013244, 2018<\/jats:p>","DOI":"10.1002\/biof.1418","type":"journal-article","created":{"date-parts":[[2018,2,22]],"date-time":"2018-02-22T11:22:43Z","timestamp":1519298563000},"page":"237-244","source":"Crossref","is-referenced-by-count":24,"title":["Dinitrosyl iron complexes: Formation and antiradical action in heart mitochondria"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8835-5188","authenticated-orcid":false,"given":"Konstantin B.","family":"Shumaev","sequence":"first","affiliation":[{"name":"A.N. 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Bach Institute of Biochemistry Research Center of Biotechnology of the Russian Academy of Sciences Moscow 119071 Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enno K.","family":"Ruuge","sequence":"additional","affiliation":[{"name":"National Medical Research Centre for Cardiology Moscow 121552 Russia"},{"name":"Faculty of Physics Lomonosov Moscow State University Moscow 119234 Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,2,22]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"81","article-title":"Free radical metabolites in myocardium during ischemia and reperfusion","volume":"261","author":"Ruuge E. K.","year":"1991","journal-title":"Am. J. 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