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The use of natural products to inhibit the aggregation process and to protect cells from cytotoxicity of early aggregate grown at the onset of the aggregation path is one of the promising strategies against AD. Recently, we have purified a new powerful antioxidant and inhibitor of A\u03b2<jats:sub>42<\/jats:sub> aggregation from the leaves of <jats:italic>Lawsonia inermis<\/jats:italic>. The new compound was identified as a new Lawsoniaside; 1,2,4\u2010trihydroxynaphthalene\u20102\u2010O\u2010\u03b2\u2010D\u2010glucopyranoside (THNG). Herein, we show that THNG interferes with A\u03b2<jats:sub>42<\/jats:sub> aggregation, inhibits its conformational change to a \u03b2\u2010sheet\u2010rich structure, decreases its polymerization into large fibrillar species, reduces oxidative stress, and aggregate cytotoxicity. 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