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The exposure of humans and animals to fluoride and\/or fluoride containing compounds is almost inevitable. This study investigated the modulatory effects of quercetin on sodium fluoride (NaF)\u2010induced hypertension and cardiovascular complications. Forty male rats were randomly separated into four groups (<jats:italic>n<\/jats:italic> =10). Group A animals served as the control, rats in Group B were exposed to 300 ppm of NaF, Groups C and D animals were exposed to 300 ppm of NaF along with quercetin orally at 50 mg\/kg and 100 mg\/kg orally by gavage, while NaF was administered in drinking water, respectively, for a week. Administration of NaF caused severe hypertension as indicated with significant increases in the systolic, diastolic, and mean arterial blood pressure, together with prolonged ventricular depolarization (QRS) and the time between the start of the Q wave and the end of the T wave in the heart's electrical cycle (QT) intervals when compared with controls. NaF significantly decreased the activities of antioxidant enzymes, caused increase in markers of oxidative stress and renal damage when compared with controls. Immunohistochemical staining revealed lower expressions of Hsp70, ERK, and PPAR\u03b3 in the heart, kidney, and aorta of rats\u2010administered NaF relative to the controls. Together, quercetin co\u2010treatment with NaF restored blood pressure, normalized QRS interval, and improved antioxidant defense system. \u00a9 2018 BioFactors, 44(5):465\u2013479, 2018<\/jats:p>","DOI":"10.1002\/biof.1445","type":"journal-article","created":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T09:10:03Z","timestamp":1535793003000},"page":"465-479","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":68,"title":["Quercetin attenuates hypertension induced by sodium fluoride via reduction in oxidative stress and modulation of HSP 70\/ERK\/PPAR\u03b3 signaling pathways"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8996-8610","authenticated-orcid":false,"given":"Ademola Adetokunbo","family":"Oyagbemi","sequence":"first","affiliation":[{"name":"Department of Veterinary Physiology and Biochemistry, Faculty of Veterinary Medicine University of Ibadan  Ibadan Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Temidayo Olutayo","family":"Omobowale","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine, Faculty of Veterinary Medicine University of Ibadan  Ibadan Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olufunke Eunice","family":"Ola\u2010Davies","sequence":"additional","affiliation":[{"name":"Department of Veterinary Physiology and Biochemistry, Faculty of Veterinary Medicine University of Ibadan  Ibadan Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ebunoluwa Racheal","family":"Asenuga","sequence":"additional","affiliation":[{"name":"Department of Veterinary Physiology and Biochemistry, Faculty of Veterinary Medicine University of Benin  Benin Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Temitayo Olabisi","family":"Ajibade","sequence":"additional","affiliation":[{"name":"Department of Veterinary Physiology and Biochemistry, Faculty of Veterinary Medicine University of Ibadan  Ibadan Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olumuyiwa Abiola","family":"Adejumobi","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine, Faculty of Veterinary Medicine University of Ibadan  Ibadan Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oluwatosin Adetola","family":"Arojojoye","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Sciences Lead City University  Ibadan Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremiah Moyinoluwa","family":"Afolabi","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine, Faculty of Veterinary Medicine University of Ibadan  Ibadan Nigeria"},{"name":"Cell Biology &amp; Physiology track, Integrated Biomedical Sciences PhD University of Tennessee Health Science Center  Memphis Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blessing Seun","family":"Ogunpolu","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine, Faculty of Veterinary Medicine University of Ibadan  Ibadan Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olufunke Olubunmi","family":"Falayi","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pharmacology and Toxicology, Faculty of Veterinary Medicine University of Ibadan  Ibadan Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fasilat Oluwakemi","family":"Hassan","sequence":"additional","affiliation":[{"name":"Department of Veterinary Physiology and Biochemistry, Faculty of Veterinary Medicine University of Ibadan  Ibadan Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace Onyeche","family":"Ochigbo","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pharmacology and Toxicology, Faculty of Veterinary Medicine University of Ibadan  Ibadan Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adebowale Benard","family":"Saba","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pharmacology and Toxicology, Faculty of Veterinary Medicine University of Ibadan  Ibadan Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adeolu Alex","family":"Adedapo","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pharmacology and Toxicology, Faculty of Veterinary Medicine University of Ibadan  Ibadan Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Momoh Audu","family":"Yakubu","sequence":"additional","affiliation":[{"name":"Department of Environmental and Interdisciplinary Sciences College of Science, Engineering and Technology, Vascular Biology Unit, Center for Cardiovascular Diseases, COPHS, Texas Southern University  Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,9]]},"reference":[{"key":"e_1_2_10_2_1","first-page":"259","article-title":"Levels of fluoride in Niger seed (Guizotia abyssinica) cultivated in Ethiopia and Eritrea","volume":"48","author":"Syume M.","year":"2015","journal-title":"Fluoride"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016350410001658"},{"key":"e_1_2_10_4_1","first-page":"1","article-title":"Water fluoridation: a critical review of the physiological effects of ingested fluoride as a public health intervention","volume":"293019","author":"Peckham S.","year":"2014","journal-title":"Sci. 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